NCT03166722 (COSGOD) is a NA clinical trial of Control group in Preterm Infant, sponsored by Medical University of Graz.

Who is sponsoring NCT03166722?

NCT03166722 is sponsored by Medical University of Graz.

What drugs are being tested in NCT03166722?

Interventions in NCT03166722: Control group, Study group.

What condition does NCT03166722 study?

NCT03166722 studies Preterm Infant, Brain Injuries, Birth Hypoxia.

Is NCT03166722 still recruiting?

NCT03166722 is currently completed. Last updated 11 February 2022.

Last reviewed 2022-02-11 · How we verify

NCT03166722: COSGOD

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Cerebral Regional Tissue Oxygen Saturation to Guide Oxygen Delivery in Preterm Neonates During Immediate Transition

Completed NA Last updated 11 February 2022

What this trial tests

NA trial testing Control group in Preterm Infant in 655 participants. Completed in 10 February 2022.

Timeline

20 September 2017

Primary endpoint
31 January 2022

10 February 2022

Quick facts

Lead sponsor	Medical University of Graz
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	diagnostic
Enrollment	655
Start date	20 September 2017
Primary completion	31 January 2022
Estimated completion	10 February 2022
Sites	12 locations across Italy, Austria, Ireland, Germany, Poland, Canada, Slovenia

Drugs / interventions tested

Control group — full drug profile →
Study group — full drug profile →

Conditions studied

Preterm Infant — all drugs for Preterm Infant →
Brain Injuries — all drugs for Brain Injuries →
Birth Hypoxia — all drugs for Birth Hypoxia →

Sponsor

Medical University of Graz

Who can join

Adults 1 Minute to 15 Minutes, any sex, with Preterm Infant or Brain Injuries. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The aim of the COSGOD Phase III trial is to examine, if it is possible to increase survival without cerebral injury in preterm neonates \<32 weeks of gestation by monitoring the cerebral tissue oxygen saturation in addition to routine monitoring of arterial oxygen saturation and heart rate and specified clinical treatment guidelines during immediate transition period after birth (the first 15 minutes).

Publications & conference data

5 peer-reviewed publications reference this trial (live from Europe PMC):

Cerebral regional tissue Oxygen Saturation to Guide Oxygen Delivery in preterm neonates during immediate transition after birth (COSGOD III): an investigator-initiated, randomized, multi-center, multi-national, clinical trial on additional cerebral tissue oxygen saturation monito
Pichler G, Baumgartner S, Biermayr M, Dempsey E, et al · · 2019 · cited 31× · PMID 30894226 · DOI 10.1186/s13063-019-3258-y
Cerebral regional tissue Oxygen Saturation to Guide Oxygen Delivery in preterm neonates during immediate transition after birth (COSGOD III): multicentre randomised phase 3 clinical trial.
Pichler G, Goeral K, Hammerl M, Perme T, et al · · 2023 · cited 30× · PMID 36693654 · DOI 10.1136/bmj-2022-072313
Reducing Brain Injury of Preterm Infants in the Delivery Room.
Viaroli F, Cheung PY, O'Reilly M, Polglase GR, et al · · 2018 · cited 10× · PMID 30386757 · DOI 10.3389/fped.2018.00290
Impact of cerebral oxygenation-guided resuscitation during immediate postnatal transition on brain injury and brain growth detected by MRI in very preterm neonates: a secondary outcome analysis of the multicenter randomized phase 3 clinical COSGOD III trial.
Hammerl M, Schreiner C, Griesmaier E, Kiechl-Kohlendorfer U, et al · · 2026 · PMID 41736052 · DOI 10.1186/s13052-026-02216-7
Effect of timing of umbilical cord clamping on cerebral regional tissue oxygenation: a secondary analysis of the COSGOD III trial.
Perme T, Kornhauser Cerar L, Schwaberger B, Urlesberger B, et al · · 2025 · PMID 40306760 · DOI 10.1136/archdischild-2024-327946

Verify or expand the search:

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Other recruiting trials for Preterm Infant

Currently open trials in the same condition.

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Other Medical University of Graz trials

Trials by the same sponsor.

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Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03166722 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Medical University of Graz
Last refreshed: 11 February 2022

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03166722.

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