Last reviewed · How we verify
NCT03156153
A Study of Bumetanide for the Treatment of Autism Spectrum Disorders
Phase 2 trial testing Bumetanide in Autism Spectrum Disorder in 120 participants. Completed in 10 July 2019.
8 July 2019
Quick facts
| Lead sponsor | Xinhua Hospital, Shanghai Jiao Tong University School of Medicine |
|---|---|
| Phase | Phase 2 |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | quadruple |
| Primary purpose | treatment |
| Enrollment | 120 |
| Start date | 24 May 2017 |
| Primary completion | 8 July 2019 |
| Estimated completion | 10 July 2019 |
| Sites | 1 location across China |
Drugs / interventions tested
- Bumetanide (BUMETANIDE) — full drug profile →
- Placebo
Conditions studied
- Autism Spectrum Disorder — all drugs for Autism Spectrum Disorder →
Sponsor
Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Who can join
Adults 3 to 6, any sex, with Autism Spectrum Disorder. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The investigators are going to carry out a randomized double-blind placebo-controlled trial to study the efficiency and mechanism of bumetanide on the treatment of children with Autism Spectrum Disorder.
Publications & conference data
4 peer-reviewed publications reference this trial (live from Europe PMC):
-
Signalling pathways in autism spectrum disorder: mechanisms and therapeutic implications.
Jiang CC, Lin LS, Long S, Ke XY, et al · · 2022 · cited 157× · PMID 35817793 · DOI 10.1038/s41392-022-01081-0 -
How Staying Negative Is Good for the (Adult) Brain: Maintaining Chloride Homeostasis and the GABA-Shift in Neurological Disorders.
Hui KK, Chater TE, Goda Y, Tanaka M. · · 2022 · cited 16× · PMID 35875665 · DOI 10.3389/fnmol.2022.893111 -
The immuno-behavioural covariation associated with the treatment response to bumetanide in young children with autism spectrum disorder.
Li Q, Zhang L, Shan H, Yu J, et al · · 2022 · cited 10× · PMID 35660740 · DOI 10.1038/s41398-022-01987-x -
Contribution of Monocarboxylate Transporter 6 to the Pharmacokinetics and Pharmacodynamics of Bumetanide in Mice.
Jones RS, Ruszaj D, Parker MD, Morris ME. · · 2020 · cited 3× · PMID 32587098 · DOI 10.1124/dmd.120.000068
Verify or expand the search:
- PubMed search for NCT03156153
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Bumetanide
Trials testing the same drug.
- NCT06941415 — Bumetanide vs. Furosemide in Cirrhosis · Phase 3 · not yet recruiting
- NCT07005414 — Efficacy of Bumetanide in Children With Autism Spectrum Disorder Guided by Peripheral Blood Biomarkers and Machine Learn · Phase 2 · recruiting
- NCT06036914 — A Study of Ultra High Dose Diuretics to Treat Heart Failure · Phase 2 · completed
- NCT06052163 — Bumetanide in Patients With Alzheimer's Disease · Phase 2 · recruiting
- NCT06465823 — Efficacy of Bumetanide to Improve Cognitive Functions in Down Syndrome · Phase 2 · recruiting
Other recruiting trials for Autism Spectrum Disorder
Currently open trials in the same condition.
- NCT07324057 — The Effects of Preoperative Intranasal Administration of Dexmedetomidine and Esketamine on Negative Postoperative Behavi · NA · recruiting
- NCT07493096 — Intensive Multimodal Neurorehabilitation Targeting Neuroplasticity in Pediatric Neurodevelopmental and Chromosomal Disor · recruiting
- NCT07505290 — Efficacy of the Korean PEERS® for Preschoolers (PEERS®-PS-K) Social Skills Intervention: A Randomized Controlled Trial f · NA · active not recruiting
- NCT07524192 — A Self-Instructional Online Program for Early Childhood and Elementary Teachers Supporting Autistic Children and Childre · NA · recruiting
- NCT07432776 — Effect of an 8-Week Pickleball Program for Adults With Autism: A Feasibility Trial With a Delayed-Control Design · EARLY_PHASE1 · recruiting
Other Xinhua Hospital, Shanghai Jiao Tong University School of Medicine trials
Trials by the same sponsor.
- NCT07506811 — Effects of Different Music Tempos on Feeding Outcomes in Preterm Infants · NA · not yet recruiting
- NCT07441187 — Efficacy and Safety of Henagliflozin, Retagliptin, and Metformin Extended-Release Tablets in Chinese Patients With Type · not yet recruiting
- NCT07375602 — A Multimodal AI Prediction Model for Complications After Transcatheter Closure of Perimembranous VSD in Children · recruiting
- NCT07405658 — Clinical Study on an Artificial Intelligence-Assisted Chest Radiograph Model Based on Big Data and Deep Learning for Ear · not yet recruiting
- NCT07381400 — Neoadjuvant mFOLFOX6 Chemotherapy Combined With Anti-PD-1 Therapy in MSS/pMMR Locally Advanced Rectal Cancer (FIRM02 Stu · Phase 2 · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03156153 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
- Last refreshed: 1 March 2021
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03156153.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing