NCT03152734 (POSE) is a clinical trial of Surgical or non-surgical intervention in Mortality, sponsored by Mark Coburn.

Who is sponsoring NCT03152734?

NCT03152734 is sponsored by Mark Coburn.

What drugs are being tested in NCT03152734?

Interventions in NCT03152734: Surgical or non-surgical intervention.

What condition does NCT03152734 study?

NCT03152734 studies Mortality, Complication, Postoperative.

Is NCT03152734 still recruiting?

NCT03152734 is currently completed. Last updated 20 November 2019.

Last reviewed 2019-11-20 · How we verify

NCT03152734: POSE

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Periinterventional Outcome Study in the Elderly

Completed Last updated 20 November 2019

What this trial tests

trial testing Surgical or non-surgical intervention in Mortality in 9,500 participants. Completed in 30 January 2019.

Timeline

1 October 2017

Primary endpoint
30 January 2019

30 January 2019

Quick facts

Lead sponsor	Mark Coburn
Status	Completed
Study type	OBSERVATIONAL
Enrollment	9,500
Start date	1 October 2017
Primary completion	30 January 2019
Estimated completion	30 January 2019
Sites	177 locations across Ireland, Poland, Denmark, Netherlands, Russia, Belgium, Portugal, France

Drugs / interventions tested

Surgical or non-surgical intervention

Conditions studied

Mortality — all drugs for Mortality →
Complication, Postoperative — all drugs for Complication, Postoperative →

Sponsor

Mark Coburn

Who can join

80 and older, any sex, with Mortality or Complication, Postoperative. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The POSE study will predict critical stages and outcome in a large sample of all surgical and non-surgical interventional patients ≥80 years of age in Europe.

Publications & conference data

7 peer-reviewed publications reference this trial (live from Europe PMC):

Peri-interventional outcome study in the elderly in Europe: A 30-day prospective cohort study.
POSE-Study group. · · 2022 · cited 25× · PMID 34799496 · DOI 10.1097/eja.0000000000001639
Association between benzodiazepine premedication and 30-day mortality rate: A propensity-score weighted analysis of the Peri-interventional Outcome Study in the Elderly (POSE).
Kowark A, Berger M, Rossaint R, Schmid M, et al · · 2022 · cited 11× · PMID 34817420 · DOI 10.1097/eja.0000000000001638
Intraoperative transfusion practices and perioperative outcome in the European elderly: A secondary analysis of the observational ETPOS study.
Grüßer L, Keszei A, Coburn M, Rossaint R, et al · · 2022 · cited 5× · PMID 34982801 · DOI 10.1371/journal.pone.0262110
Pre-Interventional Risk Assessment in The Elderly (PIRATE): Development of a scoring system to predict 30-day mortality using data of the Peri-Interventional Outcome Study in the Elderly.
Schenk A, Kowark A, Berger M, Rossaint R, et al · · 2023 · cited 2× · PMID 38127877 · DOI 10.1371/journal.pone.0294431
Characteristics and outcomes of older patients undergoing out- versus inpatient surgery in Europe. A secondary analysis of the Peri-interventional Outcome Study in the Elderly (POSE).
Grüßer L, Coburn M, Schmid M, Rossaint R, et al · · 2025 · cited 1× · PMID 40126142 · DOI 10.1111/aas.70021
Circadian effect of time of anaesthesia on postoperative outcomes in major elective and urgent intervention: a secondary analysis of the Peri-interventional Outcome Study in the Elderly (POSE).
Hoogma DF, Al Tmimi L, Fieuws S, Tournoy J, et al · · 2022 · cited 1× · PMID 39916969 · DOI 10.1097/ea9.0000000000000005
A survey study: Anesthesia in elderly patients across Europe.
Macharadze T, Lee P, Coburn M, Kowark A, et al · · 2024 · PMID 38585013 · DOI 10.1002/hsr2.2021

Verify or expand the search:

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Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03152734 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Mark Coburn
Last refreshed: 20 November 2019

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03152734.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing