NCT03152643 (CLBR-CBSET) is a NA clinical trial of blastocyst-stage embryo transfer in Infertility, sponsored by The First Affiliated Hospital with Nanjing Medical University.

Who is sponsoring NCT03152643?

NCT03152643 is sponsored by The First Affiliated Hospital with Nanjing Medical University.

What drugs are being tested in NCT03152643?

Interventions in NCT03152643: blastocyst-stage embryo transfer, cleavage-stage embryo transfer.

What condition does NCT03152643 study?

NCT03152643 studies Infertility.

Is NCT03152643 still recruiting?

NCT03152643 is currently completed. Last updated 9 June 2022.

Last reviewed 2022-06-09 · How we verify

NCT03152643: CLBR-CBSET

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Cumulative Live Birth Rates After Cleavage-stage Versus Blastocyst-stage Embryo Transfer

Completed NA Last updated 9 June 2022

What this trial tests

NA trial testing blastocyst-stage embryo transfer in Infertility in 992 participants. Completed in 18 February 2022.

Timeline

29 September 2018

Primary endpoint
6 September 2021

18 February 2022

Quick facts

Lead sponsor	The First Affiliated Hospital with Nanjing Medical University
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	treatment
Enrollment	992
Start date	29 September 2018
Primary completion	6 September 2021
Estimated completion	18 February 2022
Sites	11 locations across China

Drugs / interventions tested

blastocyst-stage embryo transfer
cleavage-stage embryo transfer

Conditions studied

Infertility — all drugs for Infertility →

Sponsor

The First Affiliated Hospital with Nanjing Medical University

Who can join

Adults 20 to 40, female only, with Infertility. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The aim of this RCT is to compare differences in the efficacy and safety between cleavage-stage embryo transfer and blastocyst-stage embryo transfer in IVF/ICSI treatment cycle, taking into account of subsequent vitrified embryo transfers. Subjects with 3 or more transferrable cleavage embryos will be randomized to the cleavage-stage or blastocyst-stage embryos transfer group. The primary outcome is cumulative live birth rate (CLBR) per patient until the first live birth from one initiated oocyte retrieval cycle, calculated using outcomes from the first three embryo transfers within 1 year after randomization.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Effect of single blastocyst-stage versus single cleavage-stage embryo transfer on cumulative live births in women with good prognosis undergoing in vitro fertilization: Multicenter Randomized Controlled Trial.
Ma X, Wang J, Shi Y, Tan J, et al · · 2024 · cited 11× · PMID 39237545 · DOI 10.1038/s41467-024-52008-y

Verify or expand the search:

Other recruiting trials for Infertility

Currently open trials in the same condition.

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NCT07340827 — A Study to Compare the Efficacy and Safety of Follitropin Alfa/Lutropin Alfa Versus hMG in Japanese Participants With LH · Phase 3 · recruiting
NCT07369362 — To Investigate if the Harvester® Improves Sperm Motility and Blastocyst Utilization (the Percent of Fertilized Eggs That · NA · active not recruiting
NCT07153367 — Using a Fixed Dosage of Follitropin Delta for Ovarian Stimulation for Intrauterine Insemination: Rekovelle for Intrauter · Phase 2 · recruiting

Other The First Affiliated Hospital with Nanjing Medical University trials

Trials by the same sponsor.

NCT07377981 — An Exploratory Study of the Efficacy and Safety of Esketamine and Dexmedetomidine in Non-Intubated ICU Patients With Hyp · Phase 4 · not yet recruiting
NCT07523789 — Comparison of Chemotherapy and Immunotherapy in Neoadjuvant Therapy for TNBC · not yet recruiting
NCT07464756 — SHR-1701 With or Without Apatinib in Combination With Chemotherapy as Neoadjuvant Therapy for Gastric Cancer · Phase 2 · not yet recruiting
NCT07482826 — Full-Endoscopic Decompression vs. Endoscopic Lumbar Fusion for Middle-Aged and Older Adults With Spinal Stenosis · NA · not yet recruiting
NCT07558863 — Effect of GLP-1RA on Cardiac Autonomic Neuropathy in Type 2 Diabetes · Phase 4 · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03152643 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by The First Affiliated Hospital with Nanjing Medical University
Last refreshed: 9 June 2022

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03152643.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing