NCT03152422 (uPROPHET) is a clinical trial of Urinary proteomics in Heart Transplantation, sponsored by KU Leuven.

Who is sponsoring NCT03152422?

NCT03152422 is sponsored by KU Leuven.

What drugs are being tested in NCT03152422?

Interventions in NCT03152422: Urinary proteomics.

What condition does NCT03152422 study?

NCT03152422 studies Heart Transplantation.

Is NCT03152422 still recruiting?

NCT03152422 is currently status unknown. Last updated 4 March 2020.

Last reviewed 2020-03-04 · How we verify

NCT03152422: uPROPHET

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Urinary Proteomics in Predicting Heart Transplantation Outcomes

Status unknown Last updated 4 March 2020

What this trial tests

trial testing Urinary proteomics in Heart Transplantation in 352 participants. Status unknown.

Timeline

1 October 2016

Primary endpoint
8 May 2017

31 December 2025

Quick facts

Lead sponsor	KU Leuven
Status	Status unknown
Study type	OBSERVATIONAL
Enrollment	352
Start date	1 October 2016
Primary completion	8 May 2017
Estimated completion	31 December 2025

Drugs / interventions tested

Urinary proteomics

Conditions studied

Heart Transplantation — all drugs for Heart Transplantation →

Sponsor

KU Leuven — full company profile →

Who can join

Adults 10 to 70, any sex, with Heart Transplantation. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

uPROPHET aims to validate urinary proteomics for risk stratification and monitoring graft performance is recipients of heart transplants

Publications & conference data

5 peer-reviewed publications reference this trial (live from Europe PMC):

Urinary Peptidomic Biomarker for Personalized Prevention and Treatment of Diastolic Left Ventricular Dysfunction.
Zhang ZY, Nkuipou-Kenfack E, Staessen JA. · · 2019 · cited 15× · PMID 30632674 · DOI 10.1002/prca.201800174
Urinary Proteomics in Predicting Heart Transplantation Outcomes (uPROPHET)-Rationale and database description.
Huang QF, Trenson S, Zhang ZY, Yang WY, et al · · 2017 · cited 10× · PMID 28880921 · DOI 10.1371/journal.pone.0184443
Urinary peptidomic biomarkers of renal function in heart transplant recipients.
Huang QF, Zhang ZY, Van Keer J, Trenson S, et al · · 2019 · cited 9× · PMID 29982668 · DOI 10.1093/ndt/gfy185
Biomarkers to Assess Right Heart Pressures in Recipients of a Heart Transplant: A Proof-of-Concept Study.
Huang QF, Trenson S, Zhang ZY, Van Keer J, et al · · 2018 · cited 7× · PMID 29796417 · DOI 10.1097/txd.0000000000000783
OSTEO18, a novel urinary proteomic signature, associated with osteoporosis in heart transplant recipients.
Yu YL, Huang QF, An DW, Raad J, et al · · 2024 · cited 2× · PMID 38312576 · DOI 10.1016/j.heliyon.2024.e24867

Verify or expand the search:

Other recruiting trials for Heart Transplantation

Currently open trials in the same condition.

NCT07359690 — Multimodal Analysis of Endomyocardial Biopsies · recruiting
NCT07096973 — Cardiac REhabilitation COhort at the Medicine Campus DaVos to invEstigate Recovery · recruiting
NCT07372820 — METABolic Deterioration in HTX Determines Outcomes · recruiting
NCT06982404 — ZeroHeart Biopsy - Prediction of Deceased Donor Heart Transplant Performance From Organ Donors Using Pre-Transplant Biop · recruiting
NCT07531784 — A National Swedish Study Evaluating Dd-cfDNA for as a Diagnostic Biomarker for Rejection Surveillence in Heart Transplan · recruiting

Other KU Leuven trials

Trials by the same sponsor.

NCT07508696 — Cerebellar Research in Ultrasound Stimulation · NA · not yet recruiting
NCT07476716 — Peer-modeled Intervention · NA · not yet recruiting
NCT07534384 — Automated CPET Interpretation: International Validation Study · not yet recruiting
NCT07419555 — Belgian Lung Function Study · recruiting
NCT07295600 — Postprandial Effect of Isocaloric Challenge Meals Enriched With Indigenous Fruits and Vegetables on Glucose Metabolism i · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03152422 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by KU Leuven
Last refreshed: 4 March 2020

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03152422.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing