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NCT03143647: MgCedVD
Magnesium and Platelet Function Testing
trial testing Collect a study-specific blood sample of healthy subjects in Eclampsia Preeclampsia in 20 participants. Completed in 1 September 2017.
30 July 2017
Quick facts
| Lead sponsor | Ziekenhuis Oost-Limburg |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 20 |
| Start date | 9 June 2017 |
| Primary completion | 30 July 2017 |
| Estimated completion | 1 September 2017 |
| Sites | 1 location across Belgium |
Drugs / interventions tested
- Collect a study-specific blood sample of healthy subjects
Conditions studied
- Eclampsia Preeclampsia — all drugs for Eclampsia Preeclampsia →
Sponsor
Ziekenhuis Oost-Limburg — full company profile →
Who can join
Adults 18 to 50, female only, with Eclampsia Preeclampsia. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Magnesium has built up the reputation of a 'natural calcium antagonist'. However, the exact effect of magnesium on coagulation and more specifically on platelet function is still disputed. An important discrepancy between in vivo and in vitro studies exists. Magnesium has thus been reported to antagonize platelets in some studies, and to stimulate platelets in other studies. Current evidence seems to point in the direction of a general antagonization of aggregation and coagulation. Intravenous magnesium is often administered in pre-eclampsia as seizure prophylaxis. Therapeutic regimens usually consist of an intravenously administered loading dose (2-3 grams) and a maintenance infusion, targeting a plasma level of 2-3 mmol/L. Therapeutic drug monitoring is needed, as magnesium toxicity is an important concern.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT03143647
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03143647 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Ziekenhuis Oost-Limburg
- Last refreshed: 18 April 2023
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03143647.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing