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NCT03142178
3VM for Treatment of Chronic Osteoarthritis Knee Pain
Phase 1, PHASE2 trial testing Experimental: 3VM1001 active 2g Cream 3 times daily in Arthritis, Degenerative in 150 participants. Completed in 1 June 2018.
30 January 2018
Quick facts
| Lead sponsor | CDA Research Group, Inc. |
|---|---|
| Phase | Phase 1, PHASE2 |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | triple |
| Primary purpose | treatment |
| Enrollment | 150 |
| Start date | 30 April 2017 |
| Primary completion | 30 January 2018 |
| Estimated completion | 1 June 2018 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Experimental: 3VM1001 active 2g Cream 3 times daily — full drug profile →
- Experimental: 3VM1001 active 3g Cream 3 times daily — full drug profile →
- Experimental: 3VM1001 active 3g Cream 4 times daily — full drug profile →
- Placebo: 3VM1001 vehicle 2g Cream 3 times daily
- Placebo: 3VM1001 vehicle 3g Cream 3 times daily — full drug profile →
- Placebo: 3VM1001 vehicle 3g Cream 4 times daily — full drug profile →
Conditions studied
- Arthritis, Degenerative — all drugs for Arthritis, Degenerative →
Sponsor
CDA Research Group, Inc.
Who can join
40 and older, any sex, with Arthritis, Degenerative. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
A double-blind, placebo-controlled, randomized dose ranging study for the use of 3VM1001 Cream, 2g three times daily, 3g three times daily, or 3g four times daily for treatment of chronic pain associated with osteoarthritis of the knee compared to inactive placebo.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Challenges and opportunities of pharmacological interventions for osteoarthritis: A review of current clinical trials and developments.
Vrouwe JPM, Burggraaf J, Kloppenburg M, Stuurman FE. · · 2021 · cited 16× · PMID 36474768 · DOI 10.1016/j.ocarto.2021.100212
Verify or expand the search:
- PubMed search for NCT03142178
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Arthritis, Degenerative
Currently open trials in the same condition.
- NCT04525950 — Robotized Navigation Compared to Conventional Technique in Total Knee Replacement · NA · active not recruiting
- NCT03312465 — Anatomical Shoulder Domelock System Study · active not recruiting
Other CDA Research Group, Inc. trials
Trials by the same sponsor.
- NCT03421613 — 3VM1001 Cream for the Treatment of Pain Associated With Post Herpetic Neuralgia (PHN) · EARLY_PHASE1 · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03142178 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by CDA Research Group, Inc.
- Last refreshed: 6 July 2018
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03142178.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing