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NCT03136562
Prevalence of Adrenal Insufficiency in Kidney Transplanted Patients in Glucocorticoid Treatment
trial testing Synacthen test in Adrenal Insufficiency in 60 participants. Completed in 1 June 2019.
1 February 2019
Quick facts
| Lead sponsor | Rigshospitalet, Denmark |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 60 |
| Start date | 20 March 2017 |
| Primary completion | 1 February 2019 |
| Estimated completion | 1 June 2019 |
| Sites | 1 location across Denmark |
Drugs / interventions tested
- Synacthen test
Conditions studied
- Adrenal Insufficiency — all drugs for Adrenal Insufficiency →
Sponsor
Rigshospitalet, Denmark
Who can join
Adults 18 to 80, any sex, with Adrenal Insufficiency. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The primary purpose of this study is to determine the prevalence of adrenal insufficiency in a population of patients with kidney transplants receiving low dose prednisone treatment. Development of glucocorticoid-induced adrenal insufficiency is a serious adverse effect to glucocorticoid treatment. The study includes a control group of patients with kidney failure currently treated in dialysis, who are not in glucocorticoid treatment. Individual genotyping is performed to determine the haplotype of glucocorticoid receptor polymorphisms: N363 S, BclI, ER23/23EK and 9β in all the patients with the purpose of investigating this as a risk factor for the development of adrenal insufficiency. The hypothesis is that subjects with one or another of the polymorphisms in the glucocorticoid receptor gene will either have increased or diminished glucocorticoid sensitivity. Using validated questionnaires assessing the quality of life and functional level of the patients enrolled in the study we aim to establish a link between functional level and biochemically proven adrenal insufficiency. Other secondary outcomes in the study includes bloodpressure, body composition, bone density, metabolic syndrome, inflammation and salivary cortisol profiles.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT03136562
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Related trials
Other recruiting trials for Adrenal Insufficiency
Currently open trials in the same condition.
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- NCT05435781 — Effect of Supplemental Hydrocortisone During Stress in Prednisolone-induced Adrenal Insufficiency · Phase 4 · recruiting
- NCT05149638 — Updated Diagnostic Cortisol Values for Adrenal Insufficiency · NA · recruiting
Other Rigshospitalet, Denmark trials
Trials by the same sponsor.
- NCT07401368 — Clinicians' Trust in AI-Based Fetal Growth Estimates · NA · not yet recruiting
- NCT07442357 — The Per-procedural Antibiotic Prophylaxis in Patients Undergoing Transcatheter Aortic Valve Implantation Trial · NA · not yet recruiting
- NCT07528729 — Alcohol as a Modifiable Risk Factor for Atrial Fibrillation · NA · not yet recruiting
- NCT07511439 — Reversible Effects of Oral Contraceptive Removal on Serotonergic Neurotransmission · Phase 4 · not yet recruiting
- NCT07467187 — Invasive Home Ventilation in Denmark · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03136562 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Rigshospitalet, Denmark
- Last refreshed: 7 April 2023
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03136562.
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