NCT03133650

A Trial of a New Type of Photodynamic Therapy (VTP) in the Treatment of Patients With Cancer of the Esophagus Who Have Trouble Swallowing

Active, enrolled Phase 1 Last updated 16 April 2026

What this trial tests

Phase 1 trial testing WST 11-mediated VTP therapy in Esophagogastric Cancer in 12 participants. Participants enrolled and being followed up; not accepting new ones.

Timeline

26 April 2017

Primary endpoint
23 February 2027

23 February 2027

Quick facts

Lead sponsor	Memorial Sloan Kettering Cancer Center
Phase	Phase 1
Status	Active, enrolled
Study type	INTERVENTIONAL
Allocation	na
Design	single group
Masking	none
Primary purpose	treatment
Enrollment	12
Start date	26 April 2017
Primary completion	23 February 2027
Estimated completion	23 February 2027
Sites	3 locations across United States, Israel

Drugs / interventions tested

• WST 11-mediated VTP therapy — full drug profile →

Conditions studied

• Esophagogastric Cancer — all drugs for Esophagogastric Cancer →
• Moderate to Severe Dysphagia — all drugs for Moderate to Severe Dysphagia →

Sponsor

Memorial Sloan Kettering Cancer Center — full company profile →

Who can join

18 and older, any sex, with Esophagogastric Cancer or Moderate to Severe Dysphagia. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The purpose of this study is to establish the highest dose of laser light for WST-11 VTP to treat obstruction from esophageal cancer that can be safely given.

Publications & conference data

6 peer-reviewed publications reference this trial (live from Europe PMC):

1. Photodynamic Therapy for the Treatment and Diagnosis of <i>Cancer</i>-A Review of the Current Clinical Status.
   Gunaydin G, Gedik ME, Ayan S. · · 2021 · cited 225× · PMID 34409014 · DOI 10.3389/fchem.2021.686303
2. Immunomodulation of the Tumor Microenvironment: Turn Foe Into Friend.
   Locy H, de Mey S, de Mey W, De Ridder M, et al · · 2018 · cited 183× · PMID 30619273 · DOI 10.3389/fimmu.2018.02909
3. Trial watch: an update of clinical advances in photodynamic therapy and its immunoadjuvant properties for cancer treatment.
   Penetra M, Arnaut LG, Gomes-da-Silva LC. · · 2023 · cited 36× · PMID 37346450 · DOI 10.1080/2162402x.2023.2226535
4. Vascular targeted photodynamic therapy: A review of the efforts towards molecular targeting of tumor vasculature.
   Mashayekhi V, Hoog CO', Oliveira S. · · 2019 · cited 29× · PMID 33568892 · DOI 10.1142/s1088424619300180
5. Validation of combined Monte Carlo and photokinetic simulations for the outcome correlation analysis of benzoporphyrin derivative-mediated photodynamic therapy on mice.
   Beeson KW, Parilov E, Potasek M, Kim MM, et al · · 2019 · cited 10× · PMID 30873764 · DOI 10.1117/1.jbo.24.3.035006
6. Comparative study of immune response to local tumor destruction modalities in a murine breast cancer model.
   Budhu S, Kim K, Yip W, La Rosa S, et al · · 2024 · PMID 38957315 · DOI 10.3389/fonc.2024.1405486