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The Inflammatory Response to Stress and Angiogenesis in Liver Resection
Patients with resectable liver metastases of colorectal origin will be assigned to laparoscopic liver resection or conventional open liver surgery. Blood samples will be drawn preoperatively and 24 hours after resection. Determination of Interleukin-6 (IL-6) and IL-8 will be done to assess the stress response between open and laparoscopic liver resection (Elisa test). The Messenger Ribonucleic Acid (mRNA) of inflammation related factors (cyclooxygenase-2 (COX-2) and Matrix metalloproteinase (MMP-9)), angiogenesis related factor (vascular endothelial growth factor (VEGF) and hypoxia induced factor-1 (HIF-1)) in tumor tissue and normal liver parenchyma will be detected by real-time real time-Polymerase Chain Reaction (RT-PCR).
Details
| Lead sponsor | University Hospital, Ghent |
|---|---|
| Phase | NA |
| Status | COMPLETED |
| Enrolment | 40 |
| Start date | Thu Apr 01 2010 00:00:00 GMT+0000 (Coordinated Universal Time) |
| Completion | Thu Jun 30 2011 00:00:00 GMT+0000 (Coordinated Universal Time) |
Conditions
- Liver Cancer
- Colorectal Cancer
- Metastatic Cancer
- Liver Metastases
Interventions
- Liver resection