NCT03130335

Intra-articular Autologous Bone Marrow Aspirate Injection for Knee Osteoarthritis

Completed NA Last updated 14 January 2020

What this trial tests

NA trial testing BMA Injection in Osteoarthritis, Knee in 13 participants. Completed in 1 October 2019.

Timeline

28 April 2017

Primary endpoint
12 August 2019

1 October 2019

Quick facts

Lead sponsor	Hospital for Special Surgery, New York
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	na
Design	single group
Masking	none
Primary purpose	treatment
Enrollment	13
Start date	28 April 2017
Primary completion	12 August 2019
Estimated completion	1 October 2019
Sites	1 location across United States

Drugs / interventions tested

• BMA Injection
• BMA — full drug profile →

Conditions studied

• Osteoarthritis, Knee — all drugs for Osteoarthritis, Knee →

Sponsor

Hospital for Special Surgery, New York

Who can join

Adults 18 to 79, any sex, with Osteoarthritis, Knee. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Knee osteoarthritis (OA) is a leading cause of disability. The objectives of treatment are to reduce pain, improve function, and slow down further breakdown of the knee. Recently, research on nonsurgical treatment options for knee OA has increased significantly. One potential treatment of interest is the use of stem cell injections. Stem cells are one's own cells that have the ability to divide into other types of cells, and may cause regrowth of cartilage when injected into the knee. There have been few, but promising, studies that show improvements in pain and function with stem cell injections in those with knee OA. Therefore, more research is needed to identify patients who might benefit from this injection. This pilot study will look at changes in pain and function for 20 patients at 1, 3, 6, and 12 months after a stem cell injection into the knee. Patients will also undergo magnetic resonance imaging at 6 months and 12 months following the injection.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

1. The Current Status of Clinical Trials on Biologics for Cartilage Repair and Osteoarthritis Treatment: An Analysis of ClinicalTrials.gov Data.
   Zhang Z, Schon L. · · 2022 · cited 21× · PMID 35546280 · DOI 10.1177/19476035221093065
2. Cellular and Clinical Analyses of Autologous Bone Marrow Aspirate Injectate for Knee Osteoarthritis: A Pilot Study.
   Wells K, Klein M, Hurwitz N, Santiago K, et al · · 2021 · cited 13× · PMID 32500620 · DOI 10.1002/pmrj.12429