NCT03128658: TrICI

Trauma Induced Coagulopathy and Inflammation

Completed Last updated 9 March 2021

What this trial tests

trial testing Thromboelastography in Trauma Injury in 300 participants. Completed in 31 December 2020.

Timeline

27 February 2017

Primary endpoint
31 December 2020

31 December 2020

Quick facts

Lead sponsor	University of Pennsylvania
Status	Completed
Study type	OBSERVATIONAL
Enrollment	300
Start date	27 February 2017
Primary completion	31 December 2020
Estimated completion	31 December 2020
Sites	1 location across United States

Drugs / interventions tested

• Thromboelastography — full drug profile →
• Computational model

Conditions studied

• Trauma Injury — all drugs for Trauma Injury →
• Trauma — all drugs for Trauma →
• Coagulopathy — all drugs for Coagulopathy →

Sponsor

University of Pennsylvania

Who can join

18 and older, any sex, with Trauma Injury or Trauma. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

While a number of factors are known to be associated with the development of trauma induced coagulopathy (TIC), inflammation, and multi-organ failure, we currently cannot predict which patients are at risk for developing these life threatening conditions with any certainty. In this prospective observational study, we will investigate the many factors that contribute to the development of trauma induced coagulopathy, post injury inflammation and the development of organ dysfunction in order to develop a multi scale computational algorithm of clinical prediction. Using a convenience sample technique, demographic data, physiologic data, blood samples and clinical variables will be collected over 5 days following traumatic injury. A computational model will be used to predict the development of TIC and multi-organ failure.

Publications & conference data

No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.