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NCT03126422
Effects of Different Doses of Dexmedetomidine on Fentanyl-induced Cough
Phase 1 trial testing Dexmedetomidine in Fentanyl-induced Cough in 240 participants. Status unknown.
1 September 2017
Quick facts
| Lead sponsor | Yangzhou University |
|---|---|
| Phase | Phase 1 |
| Status | Status unknown |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | factorial |
| Masking | double |
| Primary purpose | treatment |
| Enrollment | 240 |
| Start date | 1 May 2017 |
| Primary completion | 1 September 2017 |
| Estimated completion | 1 September 2017 |
| Sites | 1 location across China |
Drugs / interventions tested
- Dexmedetomidine (dexmedetomidine) — full drug profile →
Conditions studied
- Fentanyl-induced Cough — all drugs for Fentanyl-induced Cough →
Sponsor
Yangzhou University
Who can join
Adults 18 to 65, any sex, with Fentanyl-induced Cough. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The investigators aimed to investigate the effects of pretreatment with different doses of dexmedetomidine on the cough caused by fentanyl during anesthetic induction. Patients undergoing elective surgeries under general anesthesia will be randomly allocated to 4 groups (n = 60, each group). Dexmedetomidine 0, 0.03, 0.06, and 0.09 μg/kg/min will be pump-administered in 10 mins to groups I, II, III, and IV, respectively, followed by the induction of general anesthesia with intravenous fentanyl 4 μg/kg. The incidences and severity of cough that occurred within 2 min after the injection of fentanyl will be recorded, and the incidences of cardiovascular adverse events that occurred between the administration of the dexmedetomidine infusion and 2 min after tracheal intubation will be recorded.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Optimal dose of pretreated-dexmedetomidine in fentanyl-induced cough suppression: a prospective randomized controlled trial.
Zhou W, Zhang D, Tian S, Yang Y, et al · · 2019 · cited 9× · PMID 31153360 · DOI 10.1186/s12871-019-0765-z
Verify or expand the search:
- PubMed search for NCT03126422
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Dexmedetomidine
Trials testing the same drug.
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- NCT07398066 — DEXmedetomidine for Postoperative Analgesia and Delirium Prevention After NEUROsurgery (DEX-NEURO Trial) · NA · not yet recruiting
- NCT07377981 — An Exploratory Study of the Efficacy and Safety of Esketamine and Dexmedetomidine in Non-Intubated ICU Patients With Hyp · Phase 4 · not yet recruiting
- NCT07306702 — Dexmedetomidine-Enhanced PCIA After Lobectomy in Nicotine-Dependent Patients · Phase 4 · withdrawn
- NCT07482540 — Role of Dexmedatomidine Drug in Prevention of Atrial Fibrillations Post Mitral Valve Surgery · NA · not yet recruiting
Other Yangzhou University trials
Trials by the same sponsor.
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- NCT05909696 — Median Effective Dose of Rocuronium for the Prevention of Myofibrillation Caused by the Injection of Succinylcholine · NA · completed
- NCT05932485 — Effect of Stellate Ganglion Block on New Atrial Fibrillation After Coronary Artery Bypass Grafting · NA · completed
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03126422 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Yangzhou University
- Last refreshed: 5 July 2017
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03126422.
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