NCT03123172

The Validity of Central Venous to Arterial Co2 Difference During Living Donor Liver Transplantation

Completed NA Last updated 23 August 2017

What this trial tests

NA trial testing arterial and central venous blood gases in Liver Transplantation in 20 participants. Completed in 15 July 2017.

Timeline

25 April 2017

Primary endpoint
15 July 2017

15 July 2017

Quick facts

Lead sponsor	Kasr El Aini Hospital
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	na
Design	single group
Masking	none
Primary purpose	diagnostic
Enrollment	20
Start date	25 April 2017
Primary completion	15 July 2017
Estimated completion	15 July 2017
Sites	1 location across Egypt

Drugs / interventions tested

• arterial and central venous blood gases

Conditions studied

• Liver Transplantation — all drugs for Liver Transplantation →

Sponsor

Kasr El Aini Hospital

Who can join

18 and older, any sex, with Liver Transplantation. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Study will be conducted on 20 patients ASA III-IV undergoing orthotopic liver transplantation. Blood samples will be obtained simultaneously from arterial line, pulmonary artery catheter and central venous catheter at 4 specific time points baseline, immediately after insertion of PAC; at the end of the dissection phase; 30 minutes after anhepatic phase; 30 minutes after unclamping. Blood samples will be also obtained whenever PPV is more than 15% and patient will need fluid therapy

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

1. The validity of central venous to arterial carbon dioxide difference to predict adequate fluid management during living donor liver transplantation. A prospective observational study.
   ELAyashy M, Hosny H, Hussein A, AbdelAal Ahmed Mahmoud A, et al · · 2019 · cited 1× · PMID 31228943 · DOI 10.1186/s12871-019-0776-9
2. The Validity of Central Venous to Arterial Carbon Dioxide Difference to Predict Adequate Fluid Management during Living Donor Liver Transplantation. A prospective observational study.
   Elayashy M, Hosny H, Hussein A, Mahmoud AAA, et al · · 2019 · DOI 10.21203/rs.2.168/v2