NCT03113279

Mechanisms of Age-Related Muscle Loss

Completed Last updated 13 April 2017

What this trial tests

trial in Sarcopenic Obesity in 38 participants. Completed in 1 August 2016.

Timeline

1 August 2014

Primary endpoint
1 March 2016

1 August 2016

Quick facts

Lead sponsor	University of Birmingham
Status	Completed
Study type	OBSERVATIONAL
Enrollment	38
Start date	1 August 2014
Primary completion	1 March 2016
Estimated completion	1 August 2016

Conditions studied

• Sarcopenic Obesity — all drugs for Sarcopenic Obesity →
• Muscle Weakness — all drugs for Muscle Weakness →
• Protein Metabolism Disorder — all drugs for Protein Metabolism Disorder →
• Physical Activity — all drugs for Physical Activity →

Sponsor

University of Birmingham

Who can join

Adults 65 to 85, any sex, with Sarcopenic Obesity or Muscle Weakness. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Two independent, but interrelated conditions that have a growing impact on healthy life expectancy and health care costs in developed nations are the age related loss of muscle mass (sarcopenia) and obesity. Sarcopenia affects approximately one third of adults over 60 years of age and more than 50% of those over 80 years, which is of concern when one considers that the most rapidly expanding population demographic in the UK is adults \>80 years of age.

Skeletal muscle is important in regulating blood glucose and insulin sensitivity. Thus, sarcopenia may play a role in exacerbating insulin resistance and progression toward Type II diabetes (T2D). Indeed, the highest incidence of T2D in the UK has been noted to occur in adults \>65 years. Obesity is a major risk factor for chronic diseases including T2D and cardiovascular disease. Progression towards obesity is associated with a concomitant decrease in muscle mass, producing an unfavorable ratio of fat to muscle. Thus, obesity in old age may exacerbate the progression of sarcopenia.

For the proposed study the investigators will conduct preliminary laboratory tests to characterize body composition, insulin sensitivity, systemic inflammation, aerobic capacity and muscle protein metabolism (in the fasted and fed state) in healthy older and obese older adults for comparison against healthy young individuals.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. Age-Related Anabolic Resistance of Myofibrillar Protein Synthesis Is Exacerbated in Obese Inactive Individuals.
   Smeuninx B, Mckendry J, Wilson D, Martin U, et al · · 2017 · cited 93× · PMID 28911148 · DOI 10.1210/jc.2017-00869