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NCT03112512

A Comparison of Optimal PEEP Determination Guided by EIT and G5 Device in Moderate and Severe ARDS Patients

Completed NA Last updated 4 September 2020
What this trial tests

NA trial testing optimal PEEP guided by EIT in Acute Respiratory Distress Syndrome in 88 participants. Completed in 28 February 2019.

Timeline
20 April 2017
Primary endpoint
28 February 2019
28 February 2019

Quick facts

Lead sponsorMei-Yun Chang
PhaseNA
StatusCompleted
Study typeINTERVENTIONAL
Allocationrandomized
Designparallel
Maskingnone
Primary purposesupportive care
Enrollment88
Start date20 April 2017
Primary completion28 February 2019
Estimated completion28 February 2019
Sites1 location across Taiwan

Drugs / interventions tested

Conditions studied

Sponsor

Mei-Yun Chang

Who can join

Adults 20 to 90, any sex, with Acute Respiratory Distress Syndrome. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

To Select the Optimal Positive End-expiratory Pressure in Moderate and Severe Acute Respiratory Distress Syndrome Patients by Using: 1. the novel Non-invasive Electrical Impedance Tomography Guided Method 2. the Protective ventilation tool G5(MV)

Publications & conference data

4 peer-reviewed publications reference this trial (live from Europe PMC):

  1. Positive end-expiratory pressure titration with electrical impedance tomography and pressure-volume curve in severe acute respiratory distress syndrome.
    Zhao Z, Chang MY, Chang MY, Gow CH, et al · · 2019 · cited 81× · PMID 30656479 · DOI 10.1186/s13613-019-0484-0
  2. Positive end-expiratory pressure titration with electrical impedance tomography and pressure-volume curve: a randomized trial in moderate to severe ARDS.
    Hsu HJ, Chang HT, Zhao Z, Wang PH, et al · · 2021 · cited 63× · PMID 33361553 · DOI 10.1088/1361-6579/abd679
  3. The incidence and interpretation of large differences in EIT-based measures for PEEP titration in ARDS patients.
    Zhao Z, Lee LC, Chang MY, Frerichs I, et al · · 2020 · cited 24× · PMID 31587120 · DOI 10.1007/s10877-019-00396-8
  4. The absolute value of recruitment-to-inflation ratio does not correlate with the recruited volume.
    Zhao Z, Chang MY, Chu CC, Chang HT, et al · · 2023 · cited 3× · PMID 37344808 · DOI 10.1186/s13054-023-04520-8

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