Last reviewed · How we verify
NCT03111719
Human Brown Adipose Tissue and Mitochondrial Respiration
trial in Mitochondrial Metabolism Disorders in 180 participants. Status unknown.
10 October 2021
Quick facts
| Lead sponsor | Maastricht University Medical Center |
|---|---|
| Status | Status unknown |
| Study type | OBSERVATIONAL |
| Enrollment | 180 |
| Start date | 4 January 2010 |
| Primary completion | 10 October 2021 |
| Estimated completion | 10 October 2021 |
| Sites | 1 location across Netherlands |
Conditions studied
- Mitochondrial Metabolism Disorders — all drugs for Mitochondrial Metabolism Disorders →
- Adipose Tissue, Brown — all drugs for Adipose Tissue, Brown →
- Aging — all drugs for Aging →
- Obesity — all drugs for Obesity →
Sponsor
Maastricht University Medical Center
Who can join
Adults 18 to 65, any sex, with Mitochondrial Metabolism Disorders or Adipose Tissue, Brown. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This study is focused on measuring mitochondrial activity of human brown adipose tissue. During surgery, adipose tissue biopsies from white and brown adipose tissue will be collected from the deep neck area. These biopsies will be used to examine mitochondrial function via histological analysis, biochemical analysis and in vitro experiments based on precursor cells present in the biopsies.
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
-
Coordinated targeting of cold and nicotinic receptors synergistically improves obesity and type 2 diabetes.
Clemmensen C, Jall S, Kleinert M, Quarta C, et al · · 2018 · cited 40× · PMID 30353008 · DOI 10.1038/s41467-018-06769-y -
4-Methylumbelliferone improves the thermogenic capacity of brown adipose tissue.
Grandoch M, Flögel U, Virtue S, Maier JK, et al · · 2019 · cited 34× · PMID 31602424 · DOI 10.1038/s42255-019-0055-6
Verify or expand the search:
- PubMed search for NCT03111719
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Mitochondrial Metabolism Disorders
Currently open trials in the same condition.
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Other Maastricht University Medical Center trials
Trials by the same sponsor.
- NCT04603261 — Time to Excretion of Contrast, a Maastricht Prospective Observational Study · withdrawn
- NCT04598516 — Maastricht Investigation of Renal Function in Absence of- and Post- Contrast in Patients With eGFR LEss Than 30 · withdrawn
- NCT04597892 — Efficacy of Point-Of-Care Creatinine Assays in Patients With eGFR <30 Receiving Intravascular Contrast · withdrawn
- NCT07287358 — Optimal Cerebral Perfusion Pressure Guided Therapy: Assessment of Target Effectiveness - II · NA · not yet recruiting
- NCT07501780 — Real-world Evaluation of the Implementation of LC-OCT in Daily Clinical Practice · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03111719 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Maastricht University Medical Center
- Last refreshed: 21 February 2020
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03111719.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing