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NCT03108677
Circulating Exosome RNA in Lung Metastases of Primary High-Grade Osteosarcoma
trial testing Blood samples in Lung Metastases in 90 participants. Status unknown.
19 September 2023
Quick facts
| Lead sponsor | Ruijin Hospital |
|---|---|
| Status | Status unknown |
| Study type | OBSERVATIONAL |
| Enrollment | 90 |
| Start date | 1 May 2017 |
| Primary completion | 19 September 2023 |
| Estimated completion | 30 December 2023 |
| Sites | 1 location across China |
Drugs / interventions tested
- Blood samples — full drug profile →
Conditions studied
- Lung Metastases — all drugs for Lung Metastases →
- Osteosarcoma — all drugs for Osteosarcoma →
Sponsor
Ruijin Hospital
Who can join
Adults 12 to 60, any sex, with Lung Metastases or Osteosarcoma. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The purpose of this study is to learn whether the profile of RNA from circulating exosomes can be used as a biomarker for lung metastases of primary high-grade osteosarcoma. Circulating exosomes plays roles in metastases in many kinds of cancer including osteosarcoma. By RNA profiling researchers may find lung metastases earlier than conventional work-up and predict the oncological outcomes.
Publications & conference data
8 peer-reviewed publications reference this trial (live from Europe PMC):
-
Extracellular vesicles as tools and targets in therapy for diseases.
Kumar MA, Baba SK, Sadida HQ, Marzooqi SA, et al · · 2024 · cited 686× · PMID 38311623 · DOI 10.1038/s41392-024-01735-1 -
Exosome-based immunotherapy: a promising approach for cancer treatment.
Xu Z, Zeng S, Gong Z, Yan Y. · · 2020 · cited 373× · PMID 33183286 · DOI 10.1186/s12943-020-01278-3 -
Cancer-Derived Exosomes: Their Role in Cancer Biology and Biomarker Development.
Kok VC, Yu CC. · · 2020 · cited 318× · PMID 33116515 · DOI 10.2147/ijn.s272378 -
The Origin and Functions of Exosomes in Cancer.
Rajagopal C, Harikumar KB. · · 2018 · cited 209× · PMID 29616188 · DOI 10.3389/fonc.2018.00066 -
Regulation of cargo selection in exosome biogenesis and its biomedical applications in cancer.
Lee YJ, Shin KJ, Chae YC. · · 2024 · cited 196× · PMID 38580812 · DOI 10.1038/s12276-024-01209-y -
Progress on pivotal role and application of exosome in lung cancer carcinogenesis, diagnosis, therapy and prognosis.
Li MY, Liu LZ, Dong M. · · 2021 · cited 185× · PMID 33504342 · DOI 10.1186/s12943-021-01312-y -
Potential Use of Exosomes as Diagnostic Biomarkers and in Targeted Drug Delivery: Progress in Clinical and Preclinical Applications.
Huda MN, Nafiujjaman M, Deaguero IG, Okonkwo J, et al · · 2021 · cited 160× · PMID 33988964 · DOI 10.1021/acsbiomaterials.1c00217 -
Exosomes in the hypoxic TME: from release, uptake and biofunctions to clinical applications.
He G, Peng X, Wei S, Yang S, et al · · 2022 · cited 147× · PMID 35039054 · DOI 10.1186/s12943-021-01440-5
Verify or expand the search:
- PubMed search for NCT03108677
- Europe PMC full search
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- ESMO Meeting Library
- bioRxiv preprints
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03108677 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Ruijin Hospital
- Last refreshed: 3 October 2023
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03108677.
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