Role of Metformin on Muscle Health of Older Adults

NCT03107884 EARLY_PHASE1 ACTIVE_NOT_RECRUITING

Muscle atrophy and insulin resistance are common after bed rest in healthy older adults. Metformin treatment has been shown to improve insulin sensitivity and attenuate muscle loss in insulin resistance adults though the mechanisms are not fully known. Metformin used as a preventive strategy to maintain muscle and metabolic health in bed ridden older adults has not been investigated.

Details

Lead sponsor	University of Utah
Phase	EARLY_PHASE1
Status	ACTIVE_NOT_RECRUITING
Enrolment	64
Start date	Thu Aug 01 2019 00:00:00 GMT+0000 (Coordinated Universal Time)
Completion	Sun Nov 01 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

Conditions

• Muscle Atrophy
• Insulin Resistance

Interventions

• Metformin (Bed Rest)
• Placebo (Bed Rest)
• Metformin (2 week run-in only)
• Placebo (2 week run-in only)

Countries

United States