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NCT03100175
Strength and Aerobic Training in Elderly Lymphoma Patients During Chemotherapy and Its Impact on Treatment Outcomes, Patients Functioning and Biological Markers of Aging
NA trial testing physiotherapy in Strength Aerobic Training Elderly Lymphoma Sarcopenia Aging in 100 participants. Status unknown.
15 March 2019
Quick facts
| Lead sponsor | Rabin Medical Center |
|---|---|
| Phase | NA |
| Status | Status unknown |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | supportive care |
| Enrollment | 100 |
| Start date | 1 May 2017 |
| Primary completion | 15 March 2019 |
| Estimated completion | 15 March 2019 |
Drugs / interventions tested
- physiotherapy — full drug profile →
Conditions studied
- Strength Aerobic Training Elderly Lymphoma Sarcopenia Aging — all drugs for Strength Aerobic Training Elderly Lymphoma Sarcopenia Aging →
Sponsor
Rabin Medical Center
Who can join
70 and older, any sex, with Strength Aerobic Training Elderly Lymphoma Sarcopenia Aging. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Frailty, one of geriatric syndromes, is considered a major obstacle for recovery from physiological stress. Such stress is imposed on patients with cancer by virtue of the disease itself but even more so by the treatment. Moreover, malignancy and chemotherapy both cause accelerated loss of muscle mass, deconditioning, frailty and negative outcomes. Several studies showed that chemotherapy accelerates ageing. Muscle mass reserve was found to be a major predictor of outcomes in patients treated with chemotherapy. Recently, several studies suggest that active muscle strength training during chemotherapy may decrease side effects, improves the ability to deliver intended doses of treatment and may even affect oncological outcomes. In the proposed study we intend to assess the contribution of physical training to the well-being of chemotherapy treated older patients, assessed by molecular and physiological parameters. We intend to recruit lymphoma patients above age of 70 and prospectively and randomly assign them to the intervention group (strength, aerobic and balance training during the chemotherapy) and control group (standard care with no special emphasis on physical activity during the treatment). We will measure clinical outcomes such as treatment tolerance and effects as well as physiological outcomes (muscle strength and mass, elements activities of daily living) and laboratory markers of ageing such as DNA methylation, INK 4a expression, telomere length and serum levels of inteleukin 6, CRP among others. Our hypothesis is that physical training will improve patients' ability to complete the treatment with fewer side effects, will provide them with better daily functioning and better muscle strength/function. We also hypothesize that the ageing process, as shown by laboratory senescence markers, will be attenuated in the intervention group.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
The effect of exercise-based interventions on health-related quality of life and physical function in older patients with cancer receiving medical antineoplastic treatments: a systematic review.
Mikkelsen MK, Juhl CB, Lund CM, Jarden M, et al · · 2020 · cited 31× · PMID 33088348 · DOI 10.1186/s11556-020-00250-w
Verify or expand the search:
- PubMed search for NCT03100175
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03100175 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Rabin Medical Center
- Last refreshed: 4 April 2017
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