NCT03096743

Evaluating Raised Intracranial Pressure Using MR Elastography

Active, enrolled NA Last updated 4 March 2026

What this trial tests

NA trial testing MR elastography in Idiopathic Intracranial Hypertension in 200 participants. Participants enrolled and being followed up; not accepting new ones.

Timeline

10 January 2017

Primary endpoint
31 December 2030

31 December 2031

Quick facts

Lead sponsor	Mayo Clinic
Phase	NA
Status	Active, enrolled
Study type	INTERVENTIONAL
Allocation	non randomized
Design	parallel
Masking	none
Primary purpose	diagnostic
Enrollment	200
Start date	10 January 2017
Primary completion	31 December 2030
Estimated completion	31 December 2031
Sites	1 location across United States

Drugs / interventions tested

• MR elastography
• MRI structural brain imaging
• Lumbar puncture — full drug profile →
• Optical Coherence Tomography (OCT) imaging
• Optic nerve B-scan ultrasound

Conditions studied

• Idiopathic Intracranial Hypertension — all drugs for Idiopathic Intracranial Hypertension →

Sponsor

Mayo Clinic

Who can join

18 and older, any sex, with Idiopathic Intracranial Hypertension. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Investigators will compare magnetic resonance (MR) elastography measurements to other forms of noninvasive methods of detecting raised intracranial pressure, including optical coherence tomography (OCT) imaging measurements of the retinal nerve fiber layer (RNFL) and indirect signs of raised intracranial pressure on magnetic resonance imaging (MRI).

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. Mechanotransduction: Exploring New Therapeutic Avenues in Central Nervous System Pathology.
   Rocha DN, Carvalho ED, Relvas JB, Oliveira MJ, et al · · 2022 · cited 21× · PMID 35573316 · DOI 10.3389/fnins.2022.861613