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NCT03095157
The Emerging Role of Resolvins in the Prevention of Chronic Pain After Thoracic Surgery
NA trial testing fractionated marine lipid concentrate derived from anchovy and sardine oil in Patients Scheduled for Thoracic Surgery/Esophagectomy Will be Enrolled in 80 participants. Status unknown.
Quick facts
| Lead sponsor | Brigham and Women's Hospital |
|---|---|
| Phase | NA |
| Status | Status unknown |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | quadruple |
| Primary purpose | prevention |
| Enrollment | 80 |
| Primary completion | 1 July 2019 |
Drugs / interventions tested
- fractionated marine lipid concentrate derived from anchovy and sardine oil
Conditions studied
- Patients Scheduled for Thoracic Surgery/Esophagectomy Will be Enrolled — all drugs for Patients Scheduled for Thoracic Surgery/Esophagectomy Will be Enrolled →
- Persistent Post Surgical Pain — all drugs for Persistent Post Surgical Pain →
Sponsor
Brigham and Women's Hospital
Who can join
Adults 18 to 80, any sex, with Patients Scheduled for Thoracic Surgery/Esophagectomy Will be Enrolled or Persistent Post Surgical Pain. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The aim of the study is to investigate whether pre-operative dysregulated systemic lipid mediator pathways are associated with increased risk for the development of persistent post surgical pain. In addition we will investigate whether treatment with an over the counter dietary supplement containing a fractionated marine lipid derivative from anchovy and sardine oil prevents the development of chronic pain after surgery.
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
-
Quenching the fires: Pro-resolving mediators, air pollution, and smoking.
Thatcher TH, Woeller CF, McCarthy CE, Sime PJ. · · 2019 · cited 23× · PMID 30759375 · DOI 10.1016/j.pharmthera.2019.02.001 -
Resolution Pharmacology: State-of-the-art and therapeutic landscape.
Perretti M, Montero-Melendez T. · · 2025 · cited 1× · PMID 41205263 · DOI 10.1016/j.pharmr.2025.100097
Verify or expand the search:
- PubMed search for NCT03095157
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03095157 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Brigham and Women's Hospital
- Last refreshed: 29 March 2017
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03095157.
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