NCT03094962

Development of a Musculoskeletal Model of the PIP Joint

Completed NA Last updated 15 November 2018

What this trial tests

NA trial testing Motion capture in Patient Specific Computational Modeling in 10 participants. Completed in 5 September 2017.

Timeline

21 January 2015

Primary endpoint
5 September 2017

5 September 2017

Quick facts

Lead sponsor	University of Southampton
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	na
Design	single group
Masking	none
Primary purpose	basic science
Enrollment	10
Start date	21 January 2015
Primary completion	5 September 2017
Estimated completion	5 September 2017
Sites	1 location across United Kingdom

Drugs / interventions tested

• Motion capture
• MR scan
• CT scan — full drug profile →

Conditions studied

• Patient Specific Computational Modeling — all drugs for Patient Specific Computational Modeling →

Sponsor

University of Southampton

Who can join

18 and older, any sex, with Patient Specific Computational Modeling. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The proximal interphalangeal (PIP) joint is the second joint in the finger from the finger tip. The outcome following replacement surgery of this joint is considered unsatisfactory. In order to improve these outcomes, it would be helpful to understand the geometry of the joint, how it moves and the forces that are involved. This can be achieved using computer models that model the bones and the soft tissues - musculoskeletal models. In order to make these models as representative as possible, they should be generated using anatomical data.

Data will initially be extracted from patients' existing magnetic resonance imaging (MRI) and computed tomography (CT) scans. This will enable the computer model to begin being constructed. In parallel to the model initialisation, anatomical and motion data of the PIP joint of healthy volunteers will be collected. The necessary data will be collected using CT and MRI scans, as well as optical motion tracking methods. These data will then be used to populate the musculoskeletal model.

Once the model is constructed, it will be used to simulate the motion of the joint and look at the effect of a simulated PIP joint replacement. This information should then provide insight as to how PIP joint replacements might be improved in future.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. Quantifying Soft Tissue Artefacts and Imaging Variability in Motion Capture of the Fingers.
   Metcalf CD, Phillips C, Forrester A, Glodowski J, et al · · 2020 · cited 12× · PMID 32076882 · DOI 10.1007/s10439-020-02476-2