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NCT03094247
Feeding Malnourished Children Different Types of Fatty Acids to Promote Neurocognitive Development
NA trial testing Amoxicillin in Severe Acute Malnutrition in 2,897 participants. Completed in 23 March 2021.
23 March 2021
Quick facts
| Lead sponsor | Washington University School of Medicine |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | quadruple |
| Primary purpose | treatment |
| Enrollment | 2,897 |
| Start date | 2 October 2017 |
| Primary completion | 23 March 2021 |
| Estimated completion | 23 March 2021 |
| Sites | 1 location across Malawi |
Drugs / interventions tested
- Amoxicillin (amoxicillin) — full drug profile →
- HO-RUTF
- D-HO-RUTF
- S-RUTF
Conditions studied
- Severe Acute Malnutrition — all drugs for Severe Acute Malnutrition →
Sponsor
Washington University School of Medicine
Who can join
Adults 6 Months to 59 Months, any sex, with Severe Acute Malnutrition. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
An appropriate balance of omega-6 and omega-3 fatty acids is important for support of neurocognitive development in healthy infants and toddlers. In young children recovering from severe acute malnutrition (SAM), excess omega-6 intake depletes omega-3 fatty acid status. This research will evaluate how novel ready-to-use therapeutic foods (RUTF) with balanced fatty acids improve the metabolic and neurocognitive effects in young children in Malawi recovering from SAM, yielding new knowledge that also has implications for development of well-nourished children.
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
-
Ready-to-use therapeutic food (RUTF) for home-based nutritional rehabilitation of severe acute malnutrition in children from six months to five years of age.
Schoonees A, Lombard MJ, Musekiwa A, Nel E, et al · · 2019 · cited 64× · PMID 31090070 · DOI 10.1002/14651858.cd009000.pub3 -
Low linoleic acid foods with added DHA given to Malawian children with severe acute malnutrition improve cognition: a randomized, triple-blinded, controlled clinical trial.
Stephenson K, Callaghan-Gillespie M, Maleta K, Nkhoma M, et al · · 2022 · cited 22× · PMID 34726694 · DOI 10.1093/ajcn/nqab363
Verify or expand the search:
- PubMed search for NCT03094247
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other recruiting trials for Severe Acute Malnutrition
Currently open trials in the same condition.
- NCT06869850 — Milk Fat Globule Membrane-Enhanced RUTF for Children With Severe Acute Malnutrition · NA · recruiting
- NCT07089329 — Efficacy of Striatin in Malnourished Children · Phase 3 · recruiting
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- NCT05994742 — An Adaptive Multi-arm Trial to Improve Clinical Outcomes Among Children Recovering From Complicated SAM · Phase 3 · active not recruiting
- NCT06593080 — The DECIDE-TB Trial; Validation of Treatment Decision Algorithms for Childhood Tuberculosis · NA · recruiting
Other Washington University School of Medicine trials
Trials by the same sponsor.
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- NCT07200089 — Recombinant Human IL-7 (NT-I7) in Relapsed/Refractory Multiple Myeloma Following BCMA CAR-T Therapy (Cilta-cel) · Phase 1 · not yet recruiting
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03094247 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Washington University School of Medicine
- Last refreshed: 19 July 2022
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03094247.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing