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NCT03094039: INSPIRE-CDH
Initiation of Resuscitation While Attached to the Cord With Congenital Diaphragmatic Hernia
NA trial testing Ventilatory support while attached to the cord in Congenital Diaphragmatic Hernia. Withdrawn.
31 August 2019
Quick facts
| Lead sponsor | University of Alberta |
|---|---|
| Phase | NA |
| Status | Withdrawn |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | double |
| Primary purpose | treatment |
| Start date | 27 April 2017 |
| Primary completion | 31 August 2019 |
| Estimated completion | 31 August 2019 |
| Sites | 1 location across Canada |
Drugs / interventions tested
- Ventilatory support while attached to the cord
- Immediate cord clamping
Conditions studied
- Congenital Diaphragmatic Hernia — all drugs for Congenital Diaphragmatic Hernia →
Sponsor
University of Alberta
Who can join
Under 10 Minutes, any sex, with Congenital Diaphragmatic Hernia. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This study aims to measure the cardio-respiratory physiological consequences of initiating resuscitation during placental transfusion (PT) with an intact umbilical cord in infants with congenital diaphragmatic hernia (CDH). PT, mainly via delayed cord clamping, has been shown to offer a higher circulating blood volume, less need for blood transfusion, less need for inotropes in infants. Currently infants with CDH receive immediate cord clamping (ICC) to facilitate immediate resuscitation including immediate intubation and mechanical ventilation. With the development of a resuscitation platform (iNSPiRE), resuscitative care can now be commenced from birth in infants with CDH to benefit from PT.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT03094039
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Congenital Diaphragmatic Hernia
Currently open trials in the same condition.
- NCT05213676 — De-implementing Inhaled Nitric Oxide for Congenital Diaphragmatic Hernia · Phase 4 · recruiting
- NCT07187206 — Safety and Efficacy of FETO in CDH Phase III · Phase 3 · recruiting
- NCT07166172 — Prospective Registry for Long-term Outcomes Following FETO in Severe Left and Right CDH · NA · recruiting
- NCT06739356 — North American Fetal Therapy Network for Long-term Outcome Following Fetoscopic Endoluminal Tracheal Occlusion in Severe · NA · recruiting
- NCT03138863 — Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia (FETO) · NA · recruiting
Other University of Alberta trials
Trials by the same sponsor.
- NCT03240900 — Electrical Stimulation for Improving Postoperative Breast Sensation · NA · not yet recruiting
- NCT04231760 — The Effect of Inhaled Nitric Oxide on Pulmonary Gas-exchange in COPD · Phase 1, PHASE2 · not yet recruiting
- NCT06649604 — Reducing Pain From Retinal Laser With Vibrational Stimulation · NA · not yet recruiting
- NCT06824077 — Reducing Days DELirious With DEXmedetomidine as Part of an Intensive Care Unit Sleep Promotion Bundle · EARLY_PHASE1 · not yet recruiting
- NCT06920914 — Effects of Minimally vs. Ultra-Processed Diets on Potassium (K) Handling in CKD · NA · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03094039 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Alberta
- Last refreshed: 3 October 2019
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03094039.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing