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NCT03093857: TAAA

Investigation of the Cerebrospinal Fluid and Further Tissue Samples for Biomarker Indicating Spinal Ischemia and Organ Failure in Patients With Thoracoabdominal Aortic Aneurysm

Status unknown Last updated 29 March 2017
What this trial tests

trial testing Determination of biomarker in Thoracoabdominal Aortic Aneurysm in 100 participants. Status unknown.

Timeline
1 June 2014
Primary endpoint
31 December 2018
31 December 2018

Quick facts

Lead sponsorRWTH Aachen University
StatusStatus unknown
Study typeOBSERVATIONAL
Enrollment100
Start date1 June 2014
Primary completion31 December 2018
Estimated completion31 December 2018
Sites1 location across Germany

Drugs / interventions tested

Conditions studied

Sponsor

RWTH Aachen University

Who can join

18 and older, any sex, with Thoracoabdominal Aortic Aneurysm. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Patients with a thoracoabdominal aortic aneurysm in need of an endovascular or open operative restructuring will be asked to participate in this study. After obtaining written consent a central venous catheter and a liquor drainage will be routinely placed during surgery. The catheter and the drainage will stay in the patients for at least 72 hours postoperatively. In total, nine measurements of the liquor and serum will be performed within a week in order to determine the following parameters: neuropeptide P, neuropeptide Y, neurofilament triplet protein (NFL), S100B, glial fibrillary protein (GFAp), lactate, glucose, or oxygen.

Publications & conference data

3 peer-reviewed publications reference this trial (live from Europe PMC):

  1. Hybrid repair versus conventional open repair for thoracic aortic arch aneurysms.
    Elhelali A, Hynes N, Devane D, Sultan S, et al · · 2021 · cited 13× · PMID 34085713 · DOI 10.1002/14651858.cd012923.pub2
  2. The Role of Ribonuclease 1 and Ribonuclease Inhibitor 1 in Acute Kidney Injury after Open and Endovascular Thoracoabdominal Aortic Aneurysm Repair.
    Zechendorf E, Gombert A, Bülow T, Frank N, et al · · 2020 · cited 6× · PMID 33066382 · DOI 10.3390/jcm9103292
  3. Macrophage Migration Inhibitory Factor Predicts Outcome in Complex Aortic Surgery.
    Gombert A, Stoppe C, Foldenauer AC, Schuerholz T, et al · · 2017 · cited 3× · PMID 29120365 · DOI 10.3390/ijms18112374

Verify or expand the search:

Other recruiting trials for Thoracoabdominal Aortic Aneurysm

Currently open trials in the same condition.

Other RWTH Aachen University trials

Trials by the same sponsor.

Verify against primary sources

Data sources for this page

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03093857.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing