NCT03092843 (SPIRIT-HCM) is a clinical trial in Hypertrophic Cardiomyopathy, sponsored by The Cleveland Clinic.

Who is sponsoring NCT03092843?

NCT03092843 is sponsored by The Cleveland Clinic.

What condition does NCT03092843 study?

NCT03092843 studies Hypertrophic Cardiomyopathy.

Is NCT03092843 still recruiting?

NCT03092843 is currently completed. Last updated 7 August 2023.

Last reviewed 2023-08-07 · How we verify

NCT03092843: SPIRIT-HCM

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Functional Capacity and Quality of Life Following Septal Myectomy in Patients With HCM

Completed Last updated 7 August 2023

What this trial tests

trial in Hypertrophic Cardiomyopathy in 177 participants. Completed in 30 March 2023.

Timeline

20 March 2017

Primary endpoint
30 March 2023

30 March 2023

Quick facts

Lead sponsor	The Cleveland Clinic
Status	Completed
Study type	OBSERVATIONAL
Enrollment	177
Start date	20 March 2017
Primary completion	30 March 2023
Estimated completion	30 March 2023
Sites	1 location across United States

Conditions studied

Hypertrophic Cardiomyopathy — all drugs for Hypertrophic Cardiomyopathy →

Sponsor

The Cleveland Clinic

Who can join

Adults 18 to 65, any sex, with Hypertrophic Cardiomyopathy. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Investigators aim to assess changes in exercise capacity and quality of life after septal myectomy in patient with hypertrophic cardiomyopathy.

Publications & conference data

3 peer-reviewed publications reference this trial (live from Europe PMC):

Association of Septal Myectomy With Quality of Life in Patients With Left Ventricular Outflow Tract Obstruction From Hypertrophic Cardiomyopathy.
Desai MY, Tower-Rader A, Szpakowski N, Mentias A, et al · · 2022 · cited 27× · PMID 35420667 · DOI 10.1001/jamanetworkopen.2022.7293
Patient reported outcomes in obstructive hypertrophic cardiomyopathy undergoing myectomy: Results from SPIRIT-HCM study.
Tower-Rader A, Szpakowski N, Popovic ZB, Bittel B, et al · · 2023 · cited 13× · PMID 37302651 · DOI 10.1016/j.pcad.2023.06.001
Echocardiographic Changes Following Surgical Myectomy in Severely Symptomatic Obstructive Hypertrophic Cardiomyopathy: Insights From the SPIRIT-HCM Study.
Desai MY, Szpakowski N, Tower-Rader A, Bittel B, et al · · 2025 · cited 4× · PMID 39719417 · DOI 10.1161/jaha.124.037058

Verify or expand the search:

Other recruiting trials for Hypertrophic Cardiomyopathy

Currently open trials in the same condition.

NCT07361289 — A Study to Assess the Real-World Effectiveness of Mavacamten in Adult Patients With Obstructive Hypertrophic Cardiomyopa · recruiting
NCT06490250 — Comparison of the Effects of Inspiratory Muscle Training and Baduanjin Exercises in Hypertrophic Cardiomyopathy Patients · NA · recruiting
NCT06573723 — Institutional Registry of Rare Diseases · recruiting
NCT06549608 — A Retrospective Cohort Study of Mavacamten Patient Support Program in Canada · active not recruiting
NCT05939700 — Mavacamten Pregnancy Surveillance Program · recruiting

Other The Cleveland Clinic trials

Trials by the same sponsor.

NCT07218198 — Clinical Decision Support Tool for the Treatment of Uncontrolled Hypertension · NA · not yet recruiting
NCT07442747 — Neural Mechanisms of Aerobic Exercise Benefits in PD With DBS · NA · not yet recruiting
NCT07471464 — Centered Surgery - Preoperative Counseling and Patient Satisfaction · recruiting
NCT07073963 — Virtual Patient Groups for Sarcoidosis Associated Fatigue · NA · recruiting
NCT07363343 — Nifedipine and Enalapril vs Nifedipine and Labetalol for the Treatment of Postpartum Hypertension Study · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03092843 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by The Cleveland Clinic
Last refreshed: 7 August 2023

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03092843.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing