NCT03091790

Mesh Type in Ventral Hernia Repair

Completed NA Last updated 22 June 2023

What this trial tests

NA trial testing Synthetic Mesh in Ventral Hernia in 87 participants. Completed in 31 July 2021.

Timeline

27 March 2017

Primary endpoint
26 July 2020

31 July 2021

Quick facts

Lead sponsor	The University of Texas Health Science Center, Houston
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	double
Primary purpose	treatment
Enrollment	87
Start date	27 March 2017
Primary completion	26 July 2020
Estimated completion	31 July 2021
Sites	1 location across United States

Drugs / interventions tested

• Synthetic Mesh
• Biologic Mesh

Conditions studied

• Ventral Hernia — all drugs for Ventral Hernia →

Sponsor

The University of Texas Health Science Center, Houston

Who can join

18 and older, any sex, with Ventral Hernia. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Ventral hernias are common following abdominal surgery. Currently, there is no equipoise on when synthetic and biologic meshes should be used. Among open ventral hernia repairs, half are repaired using biologic mesh while half are repaired using synthetic mesh. The investigators hypothesize that biologic mesh as opposed to synthetic mesh repair of open ventral hernia repair is associated with decreased risk of major complications one year after surgery.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

1. Synthetic versus Biologic Mesh for Complex Open Ventral Hernia Repair: A Pilot Randomized Controlled Trial.
   Olavarria OA, Bernardi K, Dhanani NH, Lyons NB, et al · · 2021 · cited 33× · PMID 33259771 · DOI 10.1089/sur.2020.166
2. Synthetic Versus Biologic Mesh for Complex Open Ventral Hernia Repair: 3-Year Follow-Up of a Pilot Randomized Controlled Trial.
   Dhanani NH, Lyons NB, Lee KH, Olavarria OA, et al · · 2025 · cited 1× · PMID 40071184 · DOI 10.36518/2689-0216.1761