Who is sponsoring NCT03089047?

NCT03089047 is sponsored by Duke University.

What condition does NCT03089047 study?

NCT03089047 studies Erythrocyte Transfusion.

What drugs are being tested in NCT03089047?

Interventions: Transfusion of rejuvenated and washed autolgous RBCs, Transfusion of washed autolgous RBCs.

What is the status of NCT03089047?

NCT03089047 is currently TERMINATED.

Last reviewed 2021-01-11 · How we verify

Rejuvenated RBC and VO2 Max in Healthy Subjects

NCT03089047 PHASE4 TERMINATED Results posted

To compare the physiologic benefits of rejuvenated RBCs (rejRBCs) to standards RBCs (PRBCs), we will emulate critical conditions by safely maximizing stress on the cardiovascular system, in an elective, feasible volunteer study. Maximal oxygen uptake (VO2max) will be measured in an anemic, post-donation, pre-transfusion state, and also after transfusing 14-day-old, autologous blood randomized to standard storage or standard storage with rejuvenation. We hypothesize that transfusion of standard PRBCs is less effective at increasing oxygen delivery (measured by VO2max) compared with transfusion of rejRBCs.

Details

Lead sponsor	Duke University
Phase	PHASE4
Status	TERMINATED
Enrolment	9
Start date	Fri Sep 29 2017 00:00:00 GMT+0000 (Coordinated Universal Time)
Completion	Wed Apr 18 2018 00:00:00 GMT+0000 (Coordinated Universal Time)

Conditions

Erythrocyte Transfusion

Interventions

Transfusion of rejuvenated and washed autolgous RBCs
Transfusion of washed autolgous RBCs

Countries

United States