NCT03088514 (NITRATE-TOD) is a Phase 2 clinical trial of Beetroot juice in Hypertension, sponsored by Queen Mary University of London.

Who is sponsoring NCT03088514?

NCT03088514 is sponsored by Queen Mary University of London.

What drugs are being tested in NCT03088514?

Interventions in NCT03088514: Beetroot juice.

What condition does NCT03088514 study?

NCT03088514 studies Hypertension.

Is NCT03088514 still recruiting?

NCT03088514 is currently completed. Last updated 20 February 2024.

Last reviewed 2024-02-20 · How we verify

NCT03088514: NITRATE-TOD

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Investigation of Dietary Nitrate Effects in Hypertension-induced Target Organ Damage

Completed Phase 2 Last updated 20 February 2024

What this trial tests

Phase 2 trial testing Beetroot juice in Hypertension in 149 participants. Completed in 15 November 2023.

Timeline

23 March 2017

Primary endpoint
15 November 2023

15 November 2023

Quick facts

Lead sponsor	Queen Mary University of London
Phase	Phase 2
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	quadruple
Primary purpose	treatment
Enrollment	149
Start date	23 March 2017
Primary completion	15 November 2023
Estimated completion	15 November 2023
Sites	1 location across United Kingdom

Drugs / interventions tested

Beetroot juice — full drug profile →

Conditions studied

Hypertension — all drugs for Hypertension →

Sponsor

Queen Mary University of London

Who can join

Adults 18 to 80, any sex, with Hypertension. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This study aims to determine whether dietary inorganic nitrate (in beetroot juice) is able to reduce overall thickening of the heart (left ventricular hypertrophy or LVH) and stiffness of the arteries when given to patients with persistently raised blood pressure (hypertension). Half the patients will receive the beetroot juice containing inorganic nitrate and half will receive beetroot juice from which the inorganic nitrate has been removed. The volunteers will take the juice every day for 4 months.

Publications & conference data

3 peer-reviewed publications reference this trial (live from Europe PMC):

Rethinking Endothelial Dysfunction as a Crucial Target in Fighting Heart Failure.
Premer C, Kanelidis AJ, Hare JM, Schulman IH. · · 2019 · cited 78× · PMID 30899903 · DOI 10.1016/j.mayocpiqo.2018.12.006
Inorganic nitrate attenuates cardiac dysfunction: roles for xanthine oxidoreductase and nitric oxide.
Gee LC, Massimo G, Lau C, Primus C, et al · · 2022 · cited 15× · PMID 34309015 · DOI 10.1111/bph.15636
Randomised, double-blind, placebo-controlled clinical trial investigating the effects of inorganic nitrate in hypertension-induced target organ damage: protocol of the NITRATE-TOD study in the UK.
Lau CWZ, Hamers AJP, Rathod KS, Shabbir A, et al · · 2020 · cited 4× · PMID 31969369 · DOI 10.1136/bmjopen-2019-034399

Verify or expand the search:

Other trials of Beetroot juice

Trials testing the same drug.

NCT06598488 — Beetroot Juice: A Natural Boost for Cardiovascular Health in Postmenopausal Women? · NA · completed
NCT06695429 — Supplementation With Beetroot Juice to Prevent Contrast Associated Nephropathy During Hospitalization for Acute Coronary · NA · recruiting
NCT06286748 — Beetroot Extract Supplementation Associated With an Exercise Protocol for Chronic Kidney Disease Patients · NA · recruiting
NCT06416228 — Beetroot Juice NO Cold Study · Phase 2 · recruiting
NCT06227091 — The Effect od Beetroot Juice on Forearm Muscle Strength and Muscle EMG Activity After BloodFlow Restriction · NA · enrolling by invitation

Other recruiting trials for Hypertension

Currently open trials in the same condition.

NCT07413159 — The "Check, Monitor, Control Hypertension" Study is a 24-month Randomized Trial in Houston Targeting African Americans A · NA · recruiting
NCT07361276 — Observational Study That Will Evaluate Treatment Patterns in the Management of Hypertension in the Public Primary Care S · recruiting
NCT07238556 — A Novel Digital Tool Physicians Can Use to Prescribe Exercise to Patients With Cardiovascular Disease Risk Factors · NA · recruiting
NCT07238400 — Cardiac Effects of Mineralocorticoid Receptor Antagonism After Preeclampsia · Phase 2 · recruiting
NCT07135505 — Early Time-Restricted Eating in Older Adults With Hypertension · NA · recruiting

Other Queen Mary University of London trials

Trials by the same sponsor.

NCT07246005 — LVT DURATION: Pilot Study of Anticoagulation Duration for Left Ventricular Thrombus · Phase 2 · not yet recruiting
NCT07165678 — CTCA Prior to Invasive Angiography in Post-Bypass Patients (BYPASS CTCA 2) · NA · not yet recruiting
NCT06937372 — Delivery and Implementation of a Randomised Crossover Trial on Thrombosis · NA · not yet recruiting
NCT06600438 — Slow-SPEED UK: A Double-Blind Randomised Feasibility Trial · NA · not yet recruiting
NCT06987045 — Trans and Non-binary Prostate-Specific Antigen Reference Interval Determination Study · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03088514 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Queen Mary University of London
Last refreshed: 20 February 2024

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03088514.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing