NCT03087721: Intraining-MET

High-intensity Interval, Low Volume Training in Metabolic Syndrome

Completed NA Last updated 1 August 2019

What this trial tests

NA trial testing HIIT-LV in Metabolic Syndrome in 60 participants. Completed in 31 July 2019.

Timeline

1 March 2017

Primary endpoint
31 July 2019

31 July 2019

Quick facts

Lead sponsor	Universidad de Antioquia
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	treatment
Enrollment	60
Start date	1 March 2017
Primary completion	31 July 2019
Estimated completion	31 July 2019
Sites	1 location across Colombia

Drugs / interventions tested

• HIIT-LV
• CAE

Conditions studied

• Metabolic Syndrome — all drugs for Metabolic Syndrome →
• Insulin Resistance — all drugs for Insulin Resistance →

Sponsor

Universidad de Antioquia — full company profile →

Who can join

Adults 40 to 60, any sex, with Metabolic Syndrome or Insulin Resistance. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The primary objective of the study is to compare the efficacy of an intervention with high-intensity interval, low volume training (HIIT-LV) or continuous aerobic exercise (CAE) on insulin resistance, insulin sensitivity and percentage of pancreatic β-cell function in adults with metabolic syndrome (MS).

The secondary objective is to compare the efficacy of an intervention with HIIT-LV or CAE on glycosylated hemoglobin, mass and muscle fibre type composition of right thigh and plasma levels of musclin and apelin in adults with MS.

The investigators hypothesized that HIIT-LV is more effective in decreasing insulin resistance and glycosylated hemoglobin and plasma concentrations of musclin and increasing plasma concentrations of apelin, and both mass and muscle fibre type I percentage in thigh, than CAE.

Publications & conference data

4 peer-reviewed publications reference this trial (live from Europe PMC):

1. Efficacy of high-intensity, low-volume interval training compared to continuous aerobic training on insulin resistance, skeletal muscle structure and function in adults with metabolic syndrome: study protocol for a randomized controlled clinical trial (Intraining-MET).
   Gallo-Villegas J, Aristizabal JC, Estrada M, Valbuena LH, et al · · 2018 · cited 25× · PMID 29482601 · DOI 10.1186/s13063-018-2541-7
2. Efficacy of high-intensity interval- or continuous aerobic-training on insulin resistance and muscle function in adults with metabolic syndrome: a clinical trial.
   Gallo-Villegas J, Castro-Valencia LA, Pérez L, Restrepo D, et al · · 2022 · cited 16× · PMID 34687360 · DOI 10.1007/s00421-021-04835-w
3. Efficacy of high-intensity interval training versus continuous training on serum myonectin and lipid outcomes in adults with metabolic syndrome: A post-hoc analysis of a clinical trial.
   Petro JL, Fragozo-Ramos MC, Milán AF, Aristizabal JC, et al · · 2024 · cited 7× · PMID 39024345 · DOI 10.1371/journal.pone.0307256
4. Safety of High-Intensity, Low-Volume Interval Training or Continuous Aerobic Training in Adults With Metabolic Syndrome.
   Gallo-Villegas J, Restrepo D, Pérez L, Castro-Valencia LA, et al · · 2022 · cited 5× · PMID 34870388 · DOI 10.1097/pts.0000000000000922