Who is sponsoring NCT03086148?

NCT03086148 is sponsored by Beijing Tiantan Hospital.

What drugs are being tested in NCT03086148?

Interventions in NCT03086148: Ketamine, Normal saline.

What condition does NCT03086148 study?

NCT03086148 studies Ketamine; Depressive Symptom; Neurosurgery; Perioperative Period.

Is NCT03086148 still recruiting?

NCT03086148 is currently completed. Last updated 7 July 2020.

Last reviewed 2020-07-07 · How we verify

NCT03086148

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Ketamine and Postoperative Depressive Symptom-PASSION

Completed Phase 2, PHASE3 Last updated 7 July 2020

What this trial tests

Phase 2, PHASE3 trial testing Ketamine in Ketamine; Depressive Symptom; Neurosurgery; Perioperative Period in 84 participants. Completed in 20 November 2018.

Timeline

5 July 2017

Primary endpoint
24 August 2018

20 November 2018

Quick facts

Lead sponsor	Beijing Tiantan Hospital
Phase	Phase 2, PHASE3
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	quadruple
Primary purpose	treatment
Enrollment	84
Start date	5 July 2017
Primary completion	24 August 2018
Estimated completion	20 November 2018
Sites	1 location across China

Drugs / interventions tested

Ketamine (ketamine) — full drug profile →
Normal saline

Conditions studied

Ketamine; Depressive Symptom; Neurosurgery; Perioperative Period — all drugs for Ketamine; Depressive Symptom; Neurosurgery; Perioperative Period →

Sponsor

Beijing Tiantan Hospital

Who can join

Adults 18 to 65, any sex, with Ketamine; Depressive Symptom; Neurosurgery; Perioperative Period. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Perioperative depression symptom (PDS) is one of the common mental comorbidity, and influences the clinical outcomes and prognosis. However, there is no rapid acting treatment to deal with it during the limited hospital stay. This study aims to determine whether ketamine could improve the depressive symptom of peirioperative patients. It will also examine the safety for administrating ketamine as an antidepressant intraoperatively. Meanwhile, it will show if ketamine could improve anxiety, postoperative pain or delirium. This trial also will bring great concerns on patients with perioperative mental health and explore the measures to improve their psycho-related prognosis.

Publications & conference data

3 peer-reviewed publications reference this trial (live from Europe PMC):

Antidepressants for the treatment of depression in people with cancer.
Ostuzzi G, Matcham F, Dauchy S, Barbui C, et al · · 2018 · cited 89× · PMID 29683474 · DOI 10.1002/14651858.cd011006.pub3
Antidepressants for the treatment of depression in people with cancer.
Vita G, Compri B, Matcham F, Barbui C, et al · · 2023 · cited 31× · PMID 36999619 · DOI 10.1002/14651858.cd011006.pub4
Effect of low-dose ketamine on PerioperAtive depreSsive Symptoms in patients undergoing Intracranial tumOr resectioN (PASSION): study protocol for a randomized controlled trial.
Zhou Y, Peng Y, Fang J, Sun W, et al · · 2018 · cited 6× · PMID 30157913 · DOI 10.1186/s13063-018-2831-0

Verify or expand the search:

Other trials of Ketamine

Trials testing the same drug.

NCT05945147 — Ketamine and Midazolam Infusions for CRPS: Feasibility Study · Phase 2 · withdrawn
NCT06963294 — Ketamine and Dexmedetomidine for Delirium in Joint Arthroplasty · NA · not yet recruiting
NCT07294092 — Ketamine and Propofol NeuroImaging · EARLY_PHASE1 · recruiting
NCT07197684 — Ultrasound Guided Pecs Block and Ketamine Infusion for Preventing Chronic Pain in Patients Undergoing Breast Cancer Surg · NA · not yet recruiting
NCT06231563 — Ketamine for Veterans With Parkinson's Disease · Phase 2 · recruiting

Other Beijing Tiantan Hospital trials

Trials by the same sponsor.

NCT07341854 — Dexamethasone Palmitate for Postoperative Pain · NA · not yet recruiting
NCT07527013 — Stratified Blood Pressure Management Strategy After Endovascular Treatment for Acute Ischemic Stroke · Phase 3 · not yet recruiting
NCT07520370 — Effect of Perioperative Ulinastatin on Postoperative Stroke in Patients With Brain Tumor · NA · not yet recruiting
NCT07526987 — Efficacy and Safety of Minocycline in Patients With Acute Ischaemic Stroke Receiving Intravenous Thrombolysis · Phase 3 · not yet recruiting
NCT07591207 — The Efficacy and Safety of Loxoprofen Sodium Patch in Relieving Postoperative Pain After Laparoscopic Surgery · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03086148 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Beijing Tiantan Hospital
Last refreshed: 7 July 2020

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03086148.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing