NCT03085771 (DESIRED) is a Phase 2 clinical trial of desferal in Diabetes Mellitus, Type 1, sponsored by Karolinska University Hospital.

Who is sponsoring NCT03085771?

NCT03085771 is sponsored by Karolinska University Hospital.

What drugs are being tested in NCT03085771?

Interventions in NCT03085771: desferal, Isotonic saline.

What condition does NCT03085771 study?

NCT03085771 studies Diabetes Mellitus, Type 1.

Is NCT03085771 still recruiting?

NCT03085771 is currently status unknown. Last updated 26 May 2022.

Last reviewed 2022-05-26 · How we verify

NCT03085771: DESIRED

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Desferal Administration to Improve the Impaired Reaction to Hypoxia in Diabetes

Status unknown Phase 2 Last updated 26 May 2022

What this trial tests

Phase 2 trial testing desferal in Diabetes Mellitus, Type 1 in 30 participants. Status unknown.

Timeline

1 January 2017

Primary endpoint
12 December 2023

12 December 2024

Quick facts

Lead sponsor	Karolinska University Hospital
Phase	Phase 2
Status	Status unknown
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	quadruple
Primary purpose	treatment
Enrollment	30
Start date	1 January 2017
Primary completion	12 December 2023
Estimated completion	12 December 2024
Sites	1 location across Sweden

Drugs / interventions tested

desferal (DEFEROXAMINE) — full drug profile →
Isotonic saline — full drug profile →

Conditions studied

Diabetes Mellitus, Type 1 — all drugs for Diabetes Mellitus, Type 1 →

Sponsor

Karolinska University Hospital

Who can join

Adults 18 to 55, any sex, with Diabetes Mellitus, Type 1. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The general aim of this study is to investigate the influence of systemic administration of Desferal (Deferoxamine \[DFO\]) on the response to hypoxic challenge in patients with diabetes mellitus (DM). The investigation will elucidate if DFO can restore: * the impaired angiogenetic response to hypoxia in patients with type 1 DM. * the disturbed respiratory and cardiovascular regulation in response to hypoxia in patients with DM type 1

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Ferroptosis and endoplasmic reticulum stress in rheumatoid arthritis.
Ao Q, Hu H, Huang Y. · · 2024 · cited 25× · PMID 39076977 · DOI 10.3389/fimmu.2024.1438803
Iron and Copper Homeostasis in Cardiometabolic Disease: Therapeutic Potential of Chelators.
Lachowicz JI, Gać P. · · 2026 · PMID 41901288 · DOI 10.3390/ph19030441

Verify or expand the search:

Other recruiting trials for Diabetes Mellitus, Type 1

Currently open trials in the same condition.

NCT07325461 — Feasibility Study of Extended Wear Insulin Infusion Set Options During Home Use in People With Type 1 Diabetes · NA · recruiting
NCT07305805 — A Research Study of a New Medicine NNC0363-1063 in Participants With Type 1 Diabetes · Phase 1 · recruiting
NCT06282055 — Trajectories in Insulin Sensitivity Across MEnstrual cycleS in Women With Type 1 Diabetes · recruiting
NCT06325202 — Closed Loop and Education for Hypoglycemia Awareness Restoration · NA · recruiting
NCT07160816 — A Research Study to See How Insulin Icodec Helps People With Type 1 Diabetes Control Their Blood Sugar · recruiting

Other Karolinska University Hospital trials

Trials by the same sponsor.

NCT07424690 — Catheter Ablation vs Conservative Care in Elderly Patients With Atrial Fibrillation · NA · not yet recruiting
NCT06639191 — [177Lu]Lu-AKIR001 First-in-human Study · EARLY_PHASE1 · recruiting
NCT03629977 — Timing of Renal Replacement Therapy in the Critically Ill Patients · recruiting
NCT06983197 — Iatrogenic Deficiencies in ICU Patients With Prolonged Continuous Renal Replacement Therapy · not yet recruiting
NCT06835816 — Amino Acid Supplementation in Continuous Renal Replacement Therapy · NA · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03085771 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Karolinska University Hospital
Last refreshed: 26 May 2022

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03085771.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing