NCT03080142 is a Phase 4 clinical trial of Exparel in Colorectal Surgery, sponsored by University of California, Davis.

Who is sponsoring NCT03080142?

NCT03080142 is sponsored by University of California, Davis.

What drugs are being tested in NCT03080142?

Interventions in NCT03080142: Exparel, Ropivacaine.

What condition does NCT03080142 study?

NCT03080142 studies Colorectal Surgery, TAP Blocks.

Is NCT03080142 still recruiting?

NCT03080142 is currently completed. Last updated 27 April 2021.

Are results published for NCT03080142?

Yes — primary outcome results have been posted to ClinicalTrials.gov. See the outcomes section above for details.

Last reviewed 2021-04-27 · How we verify

NCT03080142

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

TAP Block Catheters vs Liposomal Bupivacaine for Pain Control After Colorectal Surgery

Completed Phase 4 Results posted Last updated 27 April 2021

What this trial tests

Phase 4 trial testing Exparel in Colorectal Surgery in 86 participants. Completed in 29 May 2019.

Timeline

1 March 2017

Primary endpoint
29 May 2019

29 May 2019

Quick facts

Lead sponsor	University of California, Davis
Phase	Phase 4
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	treatment
Enrollment	86
Start date	1 March 2017
Primary completion	29 May 2019
Estimated completion	29 May 2019
Sites	1 location across United States

Drugs / interventions tested

Exparel — full drug profile →
Ropivacaine (ROPIVACAINE) — full drug profile →

Conditions studied

Colorectal Surgery — all drugs for Colorectal Surgery →
TAP Blocks — all drugs for TAP Blocks →

Sponsor

University of California, Davis

Who can join

Adults 18 to 90, any sex, with Colorectal Surgery or TAP Blocks. Patients with the condition only — healthy volunteers not accepted.

Results — posted to ClinicalTrials.gov

Per-arm endpoint measurements with 95% confidence intervals where reported. Source: trial results section.

Mean Opioid Consumption in Morphine Opioid Equivalents in mg Primary · 48 hours from start of surgery

Anticipate superior efficacy and pain control with liposomal bupivacaine TAP blocks measured by use of opioids (measured in oral morphine equivalents) in the first 48 hours following surgery Will use opioid consumption in morphine equivalents as a comparison

Group	Value	95% CI
Group 1	112.12	± 112.8
Group 2	97.95	± 58.15

Sponsor's own description

This is a prospective randomized study designed to compare the pain control from a single shot of liposomal bupivacaine (Exparel) against transversus abominus plane (TAP) catheters with ropivicaine bolus in patients undergoing elective colorectal surgery.

Publications & conference data

No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.

Verify or expand the search:

Other trials of Exparel

Trials testing the same drug.

NCT06349772 — Zynrelef vs Exparel: The Battle of Postoperative Pain Control After Robotic Sleeve Gastrectomy · EARLY_PHASE1 · recruiting
NCT06574022 — Post-mastectomy Recovery: Comparing Preoperative PECS-II Blocks With Intraoperative Pectoral Blocks · Phase 4 · recruiting
NCT06619340 — EXPAREL IPSA Block in Knee Arthroplasty · Phase 4 · enrolling by invitation
NCT06350981 — Analgesic Requirement for Post-Operative Pain Control in TLIP Interbody Fusion · Phase 2, PHASE3 · enrolling by invitation
NCT06274008 — Exparel vs. ACB With Bupivacaine for ACL Reconstruction · Phase 1 · unknown

Other recruiting trials for Colorectal Surgery

Currently open trials in the same condition.

NCT07388953 — Peripheral Autonomic Block (BAP) Plus Transversus Abdominis Plane Block (TAP) for Postoperative Analgesia After Minimall · NA · recruiting
NCT07486570 — Anastomotic Leakage Prevention by Endovascular Stenting of the Superior Mesenteric Artery · NA · recruiting
NCT07208786 — Pre-emptive Endoscopic Vacuum Therapy Reduces the Incidence of Anastomotic Leakage After Colorectal Cancer Surgery · NA · recruiting
NCT07065994 — The Effect of Virtual Reality Glasses Application on Pain and Anxiety Levels in Colorectal Surgery Patients · NA · active not recruiting
NCT06850688 — Impact of Ambulatory Continuous Monitoring Using Remote Monitoring Medicine Within Patient's Care Pathway Following Colo · NA · recruiting

Other University of California, Davis trials

Trials by the same sponsor.

NCT07024498 — Coordinating Outpatient bupreNorphiNe for Emergency Care and Continuing Treatment · NA · not yet recruiting
NCT07322133 — Dopamine vs. Norepinephrine for Hypotension in Neonates With Pulmonary Hypertension (DONE) · Phase 4 · recruiting
NCT07384767 — Efficacy and Safety of Topical Timolol in Secondary Intention Surgical Wounds Healing · Phase 2 · not yet recruiting
NCT07267494 — Image-Guided Herniorrhaphy Study · NA · not yet recruiting
NCT04614714 — Milk Volume Outcomes Following Oral Nicotinamide Riboside Supplementation in Mothers of Extremely Preterm Infants · Phase 2, PHASE3 · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03080142 (US National Library of Medicine, public domain)
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University of California, Davis
Last refreshed: 27 April 2021

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03080142.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing