NCT03080090

YMCA Exercise Intervention for Smoking Cessation Study

Completed NA Last updated 10 September 2020

What this trial tests

NA trial testing Aerobic exercise in Nicotine Dependence in 150 participants. Completed in 6 July 2020.

Timeline

12 April 2017

Primary endpoint
6 July 2020

6 July 2020

Quick facts

Lead sponsor	University of Texas at Austin
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	treatment
Enrollment	150
Start date	12 April 2017
Primary completion	6 July 2020
Estimated completion	6 July 2020
Sites	1 location across United States

Drugs / interventions tested

• Aerobic exercise — full drug profile →
• Smoking Cessation Intervention

Conditions studied

• Nicotine Dependence — all drugs for Nicotine Dependence →

Sponsor

University of Texas at Austin

Who can join

Adults 18 to 65, any sex, with Nicotine Dependence. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Cigarette smoking is the leading cause of death and disability in the United States. Although smoking has declined since 1964, it is still very common among some groups of people. One such group is persons with emotional symptoms and disorders. There has been little success in developing treatments for smoking cessation for smokers with affective disturbances.

Recent work suggests that being sensitive to, and less tolerant of, stress is associated with many problems in daily life. People with high 'stress sensitivity' tend to use avoidant strategies to cope with their stress, like smoking. Also, people with high levels of stress sensitivity report stronger beliefs that smoking will reduce negative feelings. They also report having a harder time quitting and in fact, are less successful at doing so. This information suggests that stress sensitivity is important to target during smoking cessation treatment for smokers with affective vulnerabilities.

This clinical trial will evaluate a treatment that integrates exercise to reduce stress sensitivity among high stress sensitive smokers. It builds directly from our recent work and we now seek to adapt it to a more a more accessible and sustainable application. Results will provide important information on the benefit of an integrated intervention that could be used in the community for smokers at great risk for relapse and who do not benefit from existing alternative treatments. This study is the first to test an intervention for stress sensitive smokers and has the potential to help at-risk individuals experience quitting success and, ultimately, reduce the burden of tobacco-related cancers in Texas.

Publications & conference data

3 peer-reviewed publications reference this trial (live from Europe PMC):

1. Community-based smoking cessation treatment for adults with high anxiety sensitivity: a randomized clinical trial.
   Smits JAJ, Zvolensky MJ, Rosenfield D, Brown RA, et al · · 2021 · cited 19× · PMID 34033178 · DOI 10.1111/add.15586
2. Approach bias retraining to augment smoking cessation: A pilot randomized controlled trial.
   Smits JAJ, Rinck M, Rosenfield D, Beevers CG, et al · · 2022 · cited 4× · PMID 35917763 · DOI 10.1016/j.drugalcdep.2022.109579
3. Approach Bias and Tobacco Craving as Mechanisms of the Effect of Approach Bias Retraining on Smoking Cessation.
   Garey L, Rinck M, Rosenfield D, Nizio P, et al · · 2025 · cited 1× · PMID 39259134 · DOI 10.1093/ntr/ntae218