NCT03079180: TAGE

Tendon Adaptations to Training - Effect of Ageing

Status unknown NA Last updated 14 March 2017

What this trial tests

NA trial testing Strength training at 80% 1RM in Aging in 60 participants. Status unknown.

Timeline

13 February 2017

Primary endpoint
28 July 2017

28 July 2017

Quick facts

Lead sponsor	Université de Technologie de Compiegne
Phase	NA
Status	Status unknown
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	supportive care
Enrollment	60
Start date	13 February 2017
Primary completion	28 July 2017
Estimated completion	28 July 2017
Sites	1 location across France

Drugs / interventions tested

• Strength training at 80% 1RM
• Strength training at 55% 1RM

Conditions studied

• Aging — all drugs for Aging →
• Exercise Training — all drugs for Exercise Training →
• Connective Tissue — all drugs for Connective Tissue →
• Skeletal Muscle — all drugs for Skeletal Muscle →

Sponsor

Université de Technologie de Compiegne

Who can join

Adults 18 to 85, male only, with Aging or Exercise Training. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Tendons are essential structures for transmitting muscle forces to skeletal structures. A stiffer tendon will transmit muscle force faster, and then allow faster movement. Moreover, tendons are a living tissue and respond to mechanical forces by changing their metabolism as well as their structural and mechanical properties. The aim of the present study is to answer essential questions remaining unanswered that are necessary in order to optimize physical activity with ageing in humans, and thus improve quality of life in elderly. The main questions are: What is the minimal training intensity leading to tendon adaptations? What is the time-course of tendon adaptations? Does the same loading protocol lead to similar tendon adaptations for different tendons (Achilles vs Patellar) and does the same training program lead to identical tendon adaptations with age (25yrs vs 75yrs)? To answer these questions, tendon architecture and mechanical properties will be investigated in humans of different age and applying different training intensities. The kinematic of the tendon adaptations due to these different training characteristics will also be investigated. The training protocol will be applied on plantar flexors and knee extensors. MRI and ultrasound techniques as well as the use of ankle and knee ergometers will allow the quantification of possible modifications in tendon architecture and mechanical properties (tendon stiffness and Young's Modulus). This will be assessed in vivo, using ultrasound images to assess tendon displacement during an incremental maximal contraction.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

1. Muscles adaptation to aging and training: architectural changes - a randomised trial.
   Létocart AJ, Mabesoone F, Charleux F, Couppé C, et al · · 2021 · cited 30× · PMID 33441116 · DOI 10.1186/s12877-020-02000-0
2. Muscles adaptation to aging and training: Architectural changes - A randomised trial
   LÉTOCART AJ, Mabesoone F, Charleux F, Couppé C, et al · · 2021 · DOI 10.21203/rs.3.rs-48408/v3