NCT03078452

Evaluating Effectiveness of Powered Drill Bone Marrow Biopsy

Completed NA Results posted Last updated 8 September 2025

What this trial tests

NA trial testing Power drill in Plasma Cell Myeloma in 100 participants. Completed in 1 December 2023.

Timeline

14 February 2017

Primary endpoint
1 December 2023

1 December 2023

Quick facts

Lead sponsor	Emory University
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	diagnostic
Enrollment	100
Start date	14 February 2017
Primary completion	1 December 2023
Estimated completion	1 December 2023
Sites	1 location across United States

Drugs / interventions tested

• Power drill
• Jamshidi needle

Conditions studied

• Plasma Cell Myeloma — all drugs for Plasma Cell Myeloma →

Sponsor

Emory University

Who can join

Eligibility, any sex, with Plasma Cell Myeloma. Patients with the condition only — healthy volunteers not accepted.

Results — posted to ClinicalTrials.gov

Per-arm endpoint measurements with 95% confidence intervals where reported. Source: trial results section.

Bone Marrow Core Biopsy Length (in mm) and Artifacts Assessed by the Pathologist Primary · At the time of biopsy

Bone marrow biopsy length is studied with mean, median, range, and standard deviation and compared by two-sample t-test.

Group	Value	95% CI
Arm I (Biopsy Using Power Drill)	14	5 – 30
Arm II (Biopsy Using Jamshidi Needle)	9.5	3 – 23

Intensity of Pain Measured Using Visual Analogue Scale (VAS) Pain Questionnaire Secondary · At the time of, 30 minutes, 1, 3, and 7 days after biopsy

The VAS (visual analogue scale) for pain is on a 10 point scale. Pain is studied with chi-square, Mann Whitney U test, or Fisher's exact test. The pain scale used was 0-10, with 0 being no pain and 10 being the worst pain.

30 minutes

Group	Value	95% CI
Arm I (Biopsy Using Power Drill)	.66	0 – 6
Arm II (Biopsy Using Jamshidi Needle)	.84	0 – 8

1 day after biopsy

Group	Value	95% CI
Arm I (Biopsy Using Power Drill)	1.62	0 – 10
Arm II (Biopsy Using Jamshidi Needle)	1.62	0 – 10

3 days after biopsy

Group	Value	95% CI
Arm I (Biopsy Using Power Drill)	.89	0 – 8
Arm II (Biopsy Using Jamshidi Needle)	.63	0 – 5

7 days after biopsy

Group	Value	95% CI
Arm I (Biopsy Using Power Drill)	.18	0 – 5
Arm II (Biopsy Using Jamshidi Needle)	.26	0 – 5

Time Taken by the Procedure Measured in Seconds Using a Stopwatch Secondary · At the time of biopsy

Staff members will use a stopwatch from the beginning to the completion of the procedure (skin to skin). Time taken for procedure is studied with mean, median, range, and standard deviation and compared by two-sample t-test.

Group	Value	95% CI
Arm I (Biopsy Using Power Drill)	7	3 – 24
Arm II (Biopsy Using Jamshidi Needle)	10.5	4 – 30

Sponsor's own description

Since the introduction of the Jamshidi needle in 1971, new advances in bone marrow sampling have not been seen. In 2007, a new battery-powered bone marrow biopsy system was developed. This technology, using a battery-powered drill to operate the needle accessing the posterior iliac bone, was approved by the Food and Drug Administration (FDA) and is currently commercially available.

Few randomized controlled trials (RCTs) have compared the use of the battery-powered bone marrow biopsy system to the Jamshidi needle (the traditional manual) method of bone marrow sampling. This research study is designed to evaluate the effectiveness of the Jamshidi needle compared to the battery-powered bone marrow biopsy system.

100 participants will be enrolled in this study at Emory University.

Publications & conference data

No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.