NCT03074773 is a Phase 1 clinical trial of Dexamethasone in Coarctation of Aorta, sponsored by Cairo University.

Who is sponsoring NCT03074773?

NCT03074773 is sponsored by Cairo University.

What drugs are being tested in NCT03074773?

Interventions in NCT03074773: Dexamethasone, ultrasound, paravertebral block, Bupivacaine, isotonic saline.

What condition does NCT03074773 study?

NCT03074773 studies Coarctation of Aorta.

Is NCT03074773 still recruiting?

NCT03074773 is currently completed. Last updated 19 July 2017.

Last reviewed 2017-07-19 · How we verify

NCT03074773

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

The Effect of Paravertebral Block With Dexamethasone on Intraoperative and Postoperative Analgesia in Children Undergoing Surgery for Coarctation of Aorta

Completed Phase 1 Last updated 19 July 2017

What this trial tests

Phase 1 trial testing Dexamethasone in Coarctation of Aorta in 50 participants. Completed in 15 April 2017.

Timeline

30 October 2016

Primary endpoint
30 March 2017

15 April 2017

Quick facts

Lead sponsor	Cairo University
Phase	Phase 1
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	factorial
Masking	none
Primary purpose	health services research
Enrollment	50
Start date	30 October 2016
Primary completion	30 March 2017
Estimated completion	15 April 2017
Sites	1 location across Egypt

Drugs / interventions tested

Dexamethasone (dexamethasone) — full drug profile →
ultrasound
paravertebral block — full drug profile →
Bupivacaine (BUPIVACAINE) — full drug profile →
isotonic saline — full drug profile →

Conditions studied

Coarctation of Aorta — all drugs for Coarctation of Aorta →

Sponsor

Cairo University

Who can join

Adults 4 Months to 6, any sex, with Coarctation of Aorta. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Anesthetic management for surgery of aortic coarctation needs special care due to severe pain during lateral thoracotomy incision, the intraoperative hemodynamic instability related to skin incision at lateral thoracotomy, clamping and declamping of the aorta, needs of large doses of analgesia perioperative, needs of vasodilators. Also, postoperative care of the patients after repair is very important issue. The investigators will compare the effect of para-vertebral block with bupivacaine alone or with dexamethasone on Intra and postoperative analgesia.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

The molecular mechanisms of cardiac development and related diseases.
Li Y, Du J, Deng S, Liu B, et al · · 2024 · cited 53× · PMID 39715759 · DOI 10.1038/s41392-024-02069-8
Role of dexamethasone in the para-vertebral block for pediatric patients undergoing aortic coarctation repair. randomized, double-blinded controlled study.
Saleh AH, Hassan PF, Elayashy M, Hamza HM, et al · · 2018 · cited 6× · PMID 30501611 · DOI 10.1186/s12871-018-0637-y

Verify or expand the search:

Other trials of Dexamethasone

Trials testing the same drug.

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NCT07513129 — A Phase 1 Study Of Venetoclax, Dexamethasone, Bortezomib, And Daratumumab (VDBD) For Adolescent And Young Adult Patients · Phase 1 · not yet recruiting
NCT07444710 — Testing the Addition of an Anti-Cancer Drug, Glofitamab, to the Usual Chemotherapy Treatment (Alternating R-CHOP/R-DHAP) · Phase 1 · not yet recruiting
NCT07387926 — Safety and Efficacy of Asciminib in Pediatrics and Young Adults With Relapse/Refractory (r/r) Philadelphia Positive (Ph+ · Phase 1, PHASE2 · not yet recruiting

Other recruiting trials for Coarctation of Aorta

Currently open trials in the same condition.

NCT07086989 — Cardiovascular Risk in Children With Chronic Conditions Study · recruiting
NCT06150560 — A Study of Angiotensin-II Receptor Blocker on Cardiovascular Remodeling (VALUE Trial) · Phase 3 · recruiting
NCT06768008 — An Integrated Prenatal and Postnatal Treatment Model for the Treatment of Newborns With Critical Congenital Heart Diseas · recruiting
NCT04106479 — NIRS in Congenital Heart Defects - Correlation With Echocardiography · recruiting
NCT05362721 — PV Loop & Coarctation Study · active not recruiting

Other Cairo University trials

Trials by the same sponsor.

NCT04155528 — Effect of Music Therapy on Postoperative Health Outcomes · NA · not yet recruiting
NCT07363239 — CBCT-Based Safety Distance for Implant Placement Near the Inferior Alveolar Canal · not yet recruiting
NCT07374575 — Egyptian Dental Professionals' Perspectives on the Oral Microbiome and Exosomes · not yet recruiting
NCT07381153 — In-Vitro Cytotoxicity Assessment of INOX (Nanoksa G Plus) Polymer Discs · not yet recruiting
NCT07375394 — 3D-Printed Extraoral Camera for Standardized Dental Photography · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03074773 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Cairo University
Last refreshed: 19 July 2017

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03074773.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing