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NCT03071302
Evaluation of Tomographic and Genetic Aspects of Keratoconus Patients Compared to Sounds Corneas
NA trial testing EVALUATION OF VSX1, SOD1, and TIMP3 genes in Keratoconus in 210 participants. Completed in 31 December 2016.
31 December 2016
Quick facts
| Lead sponsor | Sao Jose do Rio Preto Medical School |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | non randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | screening |
| Enrollment | 210 |
| Start date | 1 August 2015 |
| Primary completion | 31 December 2016 |
| Estimated completion | 31 December 2016 |
| Sites | 1 location across Brazil |
Drugs / interventions tested
- EVALUATION OF VSX1, SOD1, and TIMP3 genes
Conditions studied
- Keratoconus — all drugs for Keratoconus →
- Keratoconus, Unspecified, Bilateral — all drugs for Keratoconus, Unspecified, Bilateral →
Sponsor
Sao Jose do Rio Preto Medical School
Who can join
Adults 10 to 60, any sex, with Keratoconus or Keratoconus, Unspecified, Bilateral. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Evaluation of tomographic (Pentacam) parameters and genetic parameters of Visual System Homeobox 1 (VSX1), Superoxide Dismutase (SOD1), Tissue Inhibitors of Metalloproteinases (TIMP3) genes of keratoconus patients diagnosed by clinical exam and topographic pattern. Basically we are screening patients that don't have keratoconus that those have keratoconus. The pentacam index of corneal curvature, thinnest point, corneal high order aberrations, posterior and anterior elevation, corneal densitometry, corneal volume were investigated. To analyze the genes, we took corneal epithelium samples of patients submitted to cross linking compared to (PRK) Photo Refractive Keratectomy ones. Also will be evaluated the genes of peripheral blood.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT03071302
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Keratoconus
Currently open trials in the same condition.
- NCT07372911 — PRoTECT: Corneal Wavefront Guided PRK + Epi-off CXL vs. PTK+Epi-off CXL in Keratoconus · NA · recruiting
- NCT07461129 — Electrophysiological Changes in Cases of Different Stages of Keratoconus · active not recruiting
- NCT06601101 — Effects of Topical Insulin on Corneal Epithelium Healing After Corneal Crosslinking in Patients With Keratoconus · Phase 3 · recruiting
- NCT05516004 — Safety and Effectiveness of the PXL-Platinum 330 System for Cornea Crosslinking in Eyes With Cornea Thinning · Phase 2 · recruiting
- NCT06798779 — Predicting Manifest Astigmatism in Keratoconus Patients. · active not recruiting
Other Sao Jose do Rio Preto Medical School trials
Trials by the same sponsor.
- NCT06230107 — The Effects of Nutritional Intervention in Participants With Eating Disorders. · NA · completed
- NCT06235762 — The Effects of Nutritional Intervention on Health Parameters in Participants With Type 2 Diabetes Mellitus · NA · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03071302 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Sao Jose do Rio Preto Medical School
- Last refreshed: 6 March 2017
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03071302.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing