NCT03068988 is a Phase 1 clinical trial of mesenchymal stem cells in Rotator Cuff Tear, sponsored by Hospital Znojmo.

Who is sponsoring NCT03068988?

NCT03068988 is sponsored by Hospital Znojmo.

What drugs are being tested in NCT03068988?

Interventions in NCT03068988: mesenchymal stem cells, without mesenchymal stem cells.

What condition does NCT03068988 study?

NCT03068988 studies Rotator Cuff Tear.

Is NCT03068988 still recruiting?

NCT03068988 is currently status unknown. Last updated 7 September 2017.

Last reviewed 2017-09-07 · How we verify

NCT03068988

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Clinical Study on Mesenchymal Stem Cells Used in the Reconstruction Surgery of the Supraspinatus Muscle Lesions

Status unknown Phase 1 Last updated 7 September 2017

What this trial tests

Phase 1 trial testing mesenchymal stem cells in Rotator Cuff Tear in 50 participants. Status unknown.

Timeline

1 January 2012

Primary endpoint
31 December 2014

31 December 2021

Quick facts

Lead sponsor	Hospital Znojmo
Phase	Phase 1
Status	Status unknown
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	triple
Primary purpose	treatment
Enrollment	50
Start date	1 January 2012
Primary completion	31 December 2014
Estimated completion	31 December 2021
Sites	1 location across Czechia

Drugs / interventions tested

mesenchymal stem cells — full drug profile →
without mesenchymal stem cells

Conditions studied

Rotator Cuff Tear — all drugs for Rotator Cuff Tear →

Sponsor

Hospital Znojmo

Who can join

Adults 18 to 60, any sex, with Rotator Cuff Tear. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The prospective randomized clinical study investigating the effect of mesenchymal stem cells on tendon healing. The objective of the study is to demonstrate the effect of concentrated bone marrow stem cells ( MSCs ) to the healing of sutured tendon of the supraspinatus muscle in comparison to the same procedure performed without MSCs. We have postulated the hypothesis that MSCs enhance the healing of the sutured supraspinatus tendon to its humeral footprint.

Publications & conference data

4 peer-reviewed publications reference this trial (live from Europe PMC):

Cell therapy to improve regeneration of skeletal muscle injuries.
Qazi TH, Duda GN, Ort MJ, Perka C, et al · · 2019 · cited 110× · PMID 30843380 · DOI 10.1002/jcsm.12416
Biomimetic Scaffolds in Skeletal Muscle Regeneration.
Mulbauer GD, Matthew HWT. · · 2019 · cited 28× · PMID 32309608 · DOI 10.15190/d.2019.3
Cell-Based Therapies for Rotator Cuff Injuries: An Updated Review of the Literature.
Hooper N, Marathe A, Jain NB, Jain NB, et al · · 2024 · cited 10× · PMID 38542113 · DOI 10.3390/ijms25063139
Epigenetic mechanisms in stem cell therapies for achilles tendinopathy.
Yuan Z, Yao Z, Mao X, Gao X, et al · · 2025 · PMID 40181824 · DOI 10.3389/fcell.2025.1516250

Verify or expand the search:

Other trials of mesenchymal stem cells

Trials testing the same drug.

NCT06416709 — Stem Cell Treatment for Lung Injury Caused by Major Infectious Diseases · Phase 1, PHASE2 · recruiting
NCT04446897 — Treatment of Chronic Medium-severe Periodontitis With Mesenchymal Stem Cells Predifferentiated in Osteogenic Direction · Phase 1, PHASE2 · completed
NCT04371601 — Safety and Effectiveness of Mesenchymal Stem Cells in the Treatment of Pneumonia of Coronavirus Disease 2019 · EARLY_PHASE1 · unknown
NCT03562065 — Treatment of Refractory Systemic Lupus Erythematosus by Allogeneic Mesenchymal Stem Cells Derived From the Umbilical Cor · Phase 1, PHASE2 · unknown
NCT03550183 — Umbilical Cord Derived Mesenchymal Stem Cells Therapy in Parkinson's Disease · Phase 1 · unknown

Other recruiting trials for Rotator Cuff Tear

Currently open trials in the same condition.

NCT07412184 — Research and Clinical Validation of a Wearable Device-Based Remote Rehabilitation System for Postoperative Rotator Cuff · NA · recruiting
NCT06918041 — FiberLocker® System Augmentation of Rotator Cuff Repairs · NA · recruiting
NCT07005063 — Rotator Cuff Tendon Repair With FiberLocker System Patch Augmentation · NA · recruiting
NCT06878391 — ISB With SSNB & ANB · NA · recruiting
NCT06766630 — Exploring the Feasibility of Silk Fibroin Surgical Mesh in Rotator Cuff Tears Repair Enhancement · Phase 2, PHASE3 · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03068988 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Hospital Znojmo
Last refreshed: 7 September 2017

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03068988.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing