NCT03065231

Lumbar Drain vs Extraventricular Drain to Prevent Vasospasm in Subarachnoid Hemorrhage

Recruiting now NA Last updated 4 March 2025

What this trial tests

NA trial testing Extraventricular Drain in Vasospasm, Intracranial in 100 participants. Currently enrolling.

Timeline

1 January 2017

Primary endpoint
4 January 2027

4 January 2027

Quick facts

Lead sponsor	University of California, San Diego
Phase	NA
Status	Recruiting now
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	treatment
Enrollment	100
Start date	1 January 2017
Primary completion	4 January 2027
Estimated completion	4 January 2027
Sites	1 location across United States

Drugs / interventions tested

• Extraventricular Drain
• Lumbar Drain

Conditions studied

• Vasospasm, Intracranial — all drugs for Vasospasm, Intracranial →
• Subarachnoid Hemorrhage — all drugs for Subarachnoid Hemorrhage →

Sponsor

University of California, San Diego

Who can join

Adults 18 to 110, any sex, with Vasospasm, Intracranial or Subarachnoid Hemorrhage. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Vasospasm is a common complication after rupture of intracranial aneurysms causing devastating neurologic deficits and death. Vasospasm has been directly associated with the amount of subarachnoid blood inside the basal cisterns. Prior literature has attempted to refine treatment of ruptured intracranial aneurysms but does not have clear guidelines on the optimal method to drain subarachnoid blood. Two methods, extraventricular drain (EVD) and lumbar drain (LD) have been compared retrospectively yet remain controversial as to which method is optimal in reducing subarachnoid blood and preventing vasospasm. This study would be a prospective randomized trial in which patients would be assigned to EVD or LD and observed to see if one method of intervention is associated with preventing clinical vasospasm, decreasing subarachnoid blood, shortening overall ICU stay, and reducing the need for a permanent ventriculoperitoneal shunt. The conclusions of this study may identify an optimal treatment modality to benefit all future patients with ruptured intracranial aneurysms.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

1. Targeting Hemoglobin to Reduce Delayed Cerebral Ischemia After Subarachnoid Hemorrhage.
   Zeineddine HA, Honarpisheh P, McBride D, Pandit PKT, et al · · 2022 · cited 31× · PMID 35157256 · DOI 10.1007/s12975-022-00995-9
2. Delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage: a narrative review.
   Marques IP, Albuquerque CRC, Souza NVO, Andrade JBC, et al · · 2025 · cited 2× · PMID 40562372 · DOI 10.1055/s-0045-1809885