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NCT03062787: EEFFEK
Early Effect of Cingal® Compared to Monovisc® in Patients With Osteoarthritis of the Knee
NA trial testing Cingal® (Hyaluronic Acid plus Triamcinolone Hexacetonide) in Osteoarthritis, Knee in 60 participants. Completed in 25 October 2017.
25 October 2017
Quick facts
| Lead sponsor | Pharmascience Inc. |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | treatment |
| Enrollment | 60 |
| Start date | 5 April 2017 |
| Primary completion | 25 October 2017 |
| Estimated completion | 25 October 2017 |
| Sites | 5 locations across Canada |
Drugs / interventions tested
- Cingal® (Hyaluronic Acid plus Triamcinolone Hexacetonide)
- Monovisc® (Sodium hyaluronate)
Conditions studied
- Osteoarthritis, Knee — all drugs for Osteoarthritis, Knee →
Sponsor
Pharmascience Inc. — full company profile →
Who can join
18 and older, any sex, with Osteoarthritis, Knee. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
It is a post-license, multicenter, randomized, single blind, controlled study comparing a single injection of Cingal® (study arm) with a single injection of Monovisc® (control arm).
Publications & conference data
3 peer-reviewed publications reference this trial (live from Europe PMC):
-
Designing functional hyaluronic acid-based hydrogels for cartilage tissue engineering.
Wang M, Deng Z, Guo Y, Xu P. · · 2022 · cited 52× · PMID 36420054 · DOI 10.1016/j.mtbio.2022.100495 -
Recent Advances in Clinical Translation of Intra-Articular Osteoarthritis Drug Delivery Systems.
DeJulius CR, Gulati S, Hasty KA, Crofford LJ, et al · · 2021 · cited 30× · PMID 33709019 · DOI 10.1002/adtp.202000088 -
Pharmaceutical therapeutics for articular regeneration and restoration: state-of-the-art technology for screening small molecular drugs.
Chen Y, Sun H, Yao X, Yu Y, et al · · 2021 · cited 9× · PMID 34783870 · DOI 10.1007/s00018-021-03983-8
Verify or expand the search:
- PubMed search for NCT03062787
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Osteoarthritis, Knee
Currently open trials in the same condition.
- NCT07509307 — AMAZE 6: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Knee · Phase 3 · recruiting
- NCT06488144 — Rehabilitation for Arthritis of The Knee: mainTaining Improvement for Veterans · Phase 3 · recruiting
- NCT07386561 — Virtual Reality Therapy and Non-Sleep Deep Rest Relaxation After Joint Arthroplasty · NA · active not recruiting
- NCT07514598 — Effect of J-Shaped Incision After Total Knee Arthroplasty (J-TKA) · NA · active not recruiting
- NCT07058623 — Nurse-Led Telehealth vs In-Person Follow-Up After Total Knee Replacement · NA · recruiting
Other Pharmascience Inc. trials
Trials by the same sponsor.
- NCT04046328 — Efficacy, Safety and Tolerability of Enteric-Coated Cholestyramine Capsules for Adult Short Bowel Syndrome · Phase 2 · terminated
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03062787 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Pharmascience Inc.
- Last refreshed: 21 April 2020
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03062787.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing