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NCT03059225
rTMS in Aphasic Patients With Neuroimage Assessments
NA trial testing repetitive transcranial magnetic stimulation (rTMS) in Stroke in 120 participants. Status unknown.
23 December 2021
Quick facts
| Lead sponsor | Taipei Veterans General Hospital, Taiwan |
|---|---|
| Phase | NA |
| Status | Status unknown |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | triple |
| Primary purpose | treatment |
| Enrollment | 120 |
| Start date | 18 February 2017 |
| Primary completion | 23 December 2021 |
| Estimated completion | 23 December 2021 |
| Sites | 1 location across Taiwan |
Drugs / interventions tested
- repetitive transcranial magnetic stimulation (rTMS)
- Sham stimulation
Conditions studied
Sponsor
Taipei Veterans General Hospital, Taiwan
Who can join
Adults 30 to 85, any sex, with Stroke or Aphasia. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The refinement of repetitive transcranial magnetic stimulation (rTMS) has highlighted its merit in terms of learning programs as a treatment for aftereffect augmentation. Nevertheless, the efficacy of synchronous rTMS protocol integrated with computer-integrated speech training is not well understood. It is also not clear regarding the efficacy of compound bi-hemispheric stimulation protocol. The aim of the study is to investigate language response to these new strategies and to determine the longevity of the therapeutic outcome. Advanced MR neuroimaging techniques, such as fMRI and DTI, are powerful tools to evaluate the concomitant nervous changes after rTMS treatment on aphasic patients. The knowledge from fMRI and DTI microstructural evolution provides insight into underlined mechanism operating the language improvement.
Publications & conference data
3 peer-reviewed publications reference this trial (live from Europe PMC):
-
Low-Frequency vs. Theta Burst Transcranial Magnetic Stimulation for the Treatment of Chronic Non-fluent Aphasia in Stroke: A Proof-of-Concept Study.
Chou TY, Wang JC, Lin MY, Tsai PY. · · 2021 · cited 14× · PMID 35095477 · DOI 10.3389/fnagi.2021.800377 -
Functional Remodeling Associated With Language Recovery After Repetitive Transcranial Magnetic Stimulation in Chronic Aphasic Stroke.
Lin BF, Yeh SC, Kao YJ, Lu CF, et al · · 2022 · cited 12× · PMID 35330805 · DOI 10.3389/fneur.2022.809843 -
Resting-State Network Changes Following Transcranial Magnetic Stimulation in Patients With Aphasia-A Randomized Controlled Study.
Lee IT, Huang CC, Hsu PC, Lin CP, et al · · 2022 · cited 5× · PMID 35088736 · DOI 10.1016/j.neurom.2021.10.004
Verify or expand the search:
- PubMed search for NCT03059225
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03059225 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Taipei Veterans General Hospital, Taiwan
- Last refreshed: 8 January 2021
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03059225.
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