NCT03056612: PREDICT

Predicting Acute-on-Chronic Liver Failure in Cirrhosis (PREDICT) Study

Completed Last updated 12 April 2019

What this trial tests

trial testing Observation protocol in Liver Cirrhosis With Acute Decompensation in 1,314 participants. Completed in 31 October 2018.

Timeline

31 March 2017

Primary endpoint
31 July 2018

31 October 2018

Quick facts

Lead sponsor	Jonel Trebicka
Status	Completed
Study type	OBSERVATIONAL
Enrollment	1,314
Start date	31 March 2017
Primary completion	31 July 2018
Estimated completion	31 October 2018
Sites	45 locations across France, Denmark, Italy, Netherlands, Slovakia, Belgium, Austria, United Kingdom

Drugs / interventions tested

• Observation protocol

Conditions studied

• Liver Cirrhosis With Acute Decompensation — all drugs for Liver Cirrhosis With Acute Decompensation →

Sponsor

Jonel Trebicka

Who can join

18 and older, any sex, with Liver Cirrhosis With Acute Decompensation. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The aim of this study is to assess prospectively the critical period prior to the development of Acute-on-Chronic Liver Failure (ACLF) (1), to uncover mechanistic and pathophysiological processes associated with the development and clinical course of ACLF (2) and to identify the precipitating events of ACLF (3).

Publications & conference data

5 peer-reviewed publications reference this trial (live from Europe PMC):

1. The PREDICT study uncovers three clinical courses of acutely decompensated cirrhosis that have distinct pathophysiology.
   Trebicka J, Fernandez J, Papp M, Caraceni P, et al · · 2020 · cited 378× · PMID 32673741 · DOI 10.1016/j.jhep.2020.06.013
2. PREDICT identifies precipitating events associated with the clinical course of acutely decompensated cirrhosis.
   Trebicka J, Fernandez J, Papp M, Caraceni P, et al · · 2021 · cited 219× · PMID 33227350 · DOI 10.1016/j.jhep.2020.11.019
3. Gut-Liver Axis Links Portal Hypertension to Acute-on-Chronic Liver Failure.
   Trebicka J, Reiberger T, Laleman W. · · 2018 · cited 38× · PMID 30345284 · DOI 10.1159/000490262
4. Sympathetic nervous activation, mitochondrial dysfunction and outcome in acutely decompensated cirrhosis: the metabolomic prognostic models (CLIF-C MET).
   Weiss E, de la Peña-Ramirez C, Aguilar F, Lozano JJ, et al · · 2023 · cited 30× · PMID 36788015 · DOI 10.1136/gutjnl-2022-328708
5. <i>L</i> <i>actococcus A</i> phages predict ACLF while <i>Enterococcus B</i> phages predict bacterial infection in decompensated cirrhosis.
   Van Espen L, Brol MJ, Close L, Schierwagen R, et al · · 2026 · PMID 41438339 · DOI 10.1016/j.jhepr.2025.101622