NCT03048175 (OTTO-SYST) is a NA clinical trial of Wisdom tooth removal in Tooth Impacted, sponsored by University of Pisa.

Who is sponsoring NCT03048175?

NCT03048175 is sponsored by University of Pisa.

What drugs are being tested in NCT03048175?

Interventions in NCT03048175: Wisdom tooth removal.

What condition does NCT03048175 study?

NCT03048175 studies Tooth Impacted.

Is NCT03048175 still recruiting?

NCT03048175 is currently completed. Last updated 9 February 2017.

Last reviewed 2017-02-09 · How we verify

NCT03048175: OTTO-SYST

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Acute Inflammation After Wisdom Tooth Removal

Completed NA Last updated 9 February 2017

What this trial tests

NA trial testing Wisdom tooth removal in Tooth Impacted in 40 participants. Completed in 30 June 2016.

Timeline

19 April 2007

Primary endpoint
15 June 2009

30 June 2016

Quick facts

Lead sponsor	University of Pisa
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	non randomized
Design	parallel
Masking	double
Primary purpose	treatment
Enrollment	40
Start date	19 April 2007
Primary completion	15 June 2009
Estimated completion	30 June 2016

Drugs / interventions tested

Wisdom tooth removal

Conditions studied

Tooth Impacted — all drugs for Tooth Impacted →

Sponsor

University of Pisa

Who can join

Adults 18 to 65, any sex, with Tooth Impacted. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Third molar (wisdom teeth) extraction is one of the most frequent intervention in dentistry. Nevertheless, little is known about the level of general body inflammation of subjects with impacted or semi-impacted third molars. Moreover, The possible effects of surgical removal of wisdom teeth on the overall health are not known. Thus, a study in which 40 subjects has been designed. Twenty subjects were affected by bilateral wisdom tooth pathology necessitating for extraction of both teeth. Control group comprised 20 subjects with absence of wisdom teeth or completely erupted wisdom teeth without pathology associated to or history of previous extraction of both wisdom teeth. In both groups a medical and dental examination will be performed at the baseline and 3 months after baseline for the control group or after the second third molar extraction in the control group. Blood will be also withdrawn to assess systemic inflammation and other systemic parameters. Parameter were evaluated via high sensitive c reactive protein (CRP), lipids, fibrinogen, oxidative stress and endothelial function analysis.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Systemic Inflammation after Third Molar Removal: A Case-Control Study.
Graziani F, D'Aiuto F, Gennai S, Petrini M, et al · · 2017 · cited 32× · PMID 28759304 · DOI 10.1177/0022034517722775

Verify or expand the search:

Other recruiting trials for Tooth Impacted

Currently open trials in the same condition.

NCT06778590 — Comparison of Piezoelectric and Conventional Surgery for Germectomy of the Lower Third Molar · NA · recruiting

Other University of Pisa trials

Trials by the same sponsor.

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NCT07510685 — Closed-System Bladder Irrigation to Reduce Urinary Tract Infections After Endoscopic Urologic Surgery (IRIS Trial) · NA · completed
NCT07055152 — Retinal OCTA for Microvascular Dysfunction Evaluation and Outcome Prediction in MINOCA Patients · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03048175 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 9 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University of Pisa
Last refreshed: 9 February 2017

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03048175.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing