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NCT03047772: TEAM-AMI
Transplantation Efficacy of Autologous Bone Marrow Mesenchymal Stem Cells With Intensive Atorvastatin in AMI Patients
Phase 2 trial testing Atorvastatin in Myocardial Infarction in 124 participants. Status unknown.
31 December 2018
Quick facts
| Lead sponsor | Yuejin Yang |
|---|---|
| Phase | Phase 2 |
| Status | Status unknown |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | factorial |
| Masking | triple |
| Primary purpose | treatment |
| Enrollment | 124 |
| Start date | 6 March 2018 |
| Primary completion | 31 December 2018 |
| Estimated completion | 31 December 2018 |
Drugs / interventions tested
- Atorvastatin (atorvastatin) — full drug profile →
- Intensive Atorvastatin — full drug profile →
- Low dose BMMSC — full drug profile →
- Middle dose BMMSC — full drug profile →
- High dose BMMSC — full drug profile →
- Transplantation
Conditions studied
- Myocardial Infarction — all drugs for Myocardial Infarction →
- Stem Cell Transplantation — all drugs for Stem Cell Transplantation →
- Angioplasty, Transluminal, Percutaneous Coronary — all drugs for Angioplasty, Transluminal, Percutaneous Coronary →
Sponsor
Yuejin Yang — full company profile →
Who can join
Adults 30 to 75, any sex, with Myocardial Infarction or Stem Cell Transplantation. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The benefit of current stem cell transplantation therapy for myocardial infarction is limited by low survival rate for stem cell. The purpose of this study is to test whether intensive Atorvastatin therapy can improve the outcome of patients with impaired left ventricle function after acute myocardial infarction who underwent intracoronary transfer of autologous bone marrow mesenchymal stem cells.
Publications & conference data
6 peer-reviewed publications reference this trial (live from Europe PMC):
-
Clinical application of mesenchymal stem cell in regenerative medicine: a narrative review.
Margiana R, Margiana R, Margiana R, Markov A, et al · · 2022 · cited 263× · PMID 35902958 · DOI 10.1186/s13287-022-03054-0 -
Concise Review: Rational Use of Mesenchymal Stem Cells in the Treatment of Ischemic Heart Disease.
Ward MR, Abadeh A, Connelly KA. · · 2018 · cited 65× · PMID 29665255 · DOI 10.1002/sctm.17-0210 -
Functionally Improved Mesenchymal Stem Cells to Better Treat Myocardial Infarction.
Chen Z, Chen L, Zeng C, Wang WE. · · 2018 · cited 40× · PMID 30622568 · DOI 10.1155/2018/7045245 -
Locoregional delivery of stem cell-based therapies.
Ng NN, Thakor AS. · · 2020 · cited 24× · PMID 32522806 · DOI 10.1126/scitranslmed.aba4564 -
Transplantation efficacy of autologous bone marrow mesenchymal stem cells combined with atorvastatin for acute myocardial infarction (TEAM-AMI): rationale and design of a randomized, double-blind, placebo-controlled, multi-center, Phase II TEAM-AMI trial.
Xu JY, Qian HY, Huang PS, Xu J, et al · · 2019 · cited 9× · PMID 31829095 · DOI 10.2217/rme-2019-0024 -
Stem cell therapy for patients with acute myocardial infarction: a systematic review of clinical trials.
Mahram H, Khalafi V, Arman A, Mirhosseini SA, et al · · 2025 · PMID 41469916 · DOI 10.1186/s13287-025-04882-6
Verify or expand the search:
- PubMed search for NCT03047772
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other recruiting trials for Myocardial Infarction
Currently open trials in the same condition.
- NCT07257198 — Aspirin-free Strategy With Ticagrelor in Patients With a Myocardial Infarction Treated Medically Alone · Phase 3 · recruiting
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- NCT07142265 — Evaluation of 1-Year Clinical Outcomes With Early Inclisiran Initiation in Post-MI Patients · recruiting
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03047772 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Yuejin Yang
- Last refreshed: 25 January 2018
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03047772.
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