NCT03041961

Aronia Berry Consumption on Vascular Function

Completed NA Last updated 5 July 2019

What this trial tests

NA trial testing Placebo in Healthy Young Men in 66 participants. Completed in 20 July 2017.

Timeline

14 February 2017

Primary endpoint
20 July 2017

20 July 2017

Quick facts

Lead sponsor	King's College London
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	double
Primary purpose	basic science
Enrollment	66
Start date	14 February 2017
Primary completion	20 July 2017
Estimated completion	20 July 2017
Sites	1 location across United Kingdom

Drugs / interventions tested

• Placebo
• Aronia full spectrum
• Aronia extract

Conditions studied

• Healthy Young Men — all drugs for Healthy Young Men →

Sponsor

King's College London

Who can join

Adults 18 to 45, male only, with Healthy Young Men. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

There is an increasing interest in the effects of various food derived polyphenols on vascular function. Arguably the most well-established vascular benefits are attributed to flavanols from cocoa beans and this has been supported by a successful health claim through the European Food Safely Authority in 2012. Berry fruits are another rich source of polyphenols that have vasoactive properties, and there is a growing body of research exploring these effects in various berries (blueberries, cranberries, strawberries) and other fruit products with similar polyphenol composition. A key (poly)phenol in berries and other fruits believed to provide much of the benefit is anthocyanins. When given as an isolated extract, 320 mg anthocyanins have been found to improve blood vessel function both acutely and in response to chronic consumption over 12 weeks.

Aronia berries are a native North American berry with high naturally occurring anthocyanins among other polyphenols. Based on their polyphenol composition, there is growing interest in the potential for Aronia berries to elicit health promoting cardio-metabolic effects. Specifically, Aronia berry extracts, which provide a concentrated source of polyphenols, may improve blood vessel function.

Thus, the primary focus of this project is to evaluate the effects of Aronia berry extracts of differing polyphenol dose on vascular endothelial function.

Publications & conference data

4 peer-reviewed publications reference this trial (live from Europe PMC):

1. Effects of aronia berry (poly)phenols on vascular function and gut microbiota: a double-blind randomized controlled trial in adult men.
   Istas G, Wood E, Le Sayec M, Rawlings C, et al · · 2019 · cited 91× · PMID 31152545 · DOI 10.1093/ajcn/nqz075
2. Consumption of Stilbenes and Flavonoids is Linked to Reduced Risk of Obesity Independently of Fiber Intake.
   Mompeo O, Spector TD, Matey Hernandez M, Le Roy C, et al · · 2020 · cited 25× · PMID 32585900 · DOI 10.3390/nu12061871
3. Development of a (Poly)phenol Metabolic Signature for Assessing (Poly)phenol-Rich Dietary Patterns.
   Li Y, Xu Y, Le Sayec M, Yan X, et al · · 2024 · cited 6× · PMID 38829321 · DOI 10.1021/acs.jafc.4c00959
4. Development of metabolic signatures of plant-rich dietary patterns using plant-derived metabolites.
   Li Y, Xu Y, Sayec ML, Spector TD, et al · · 2024 · cited 2× · PMID 39604558 · DOI 10.1007/s00394-024-03511-x