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NCT03033147
Effect of Preoperative Amoxicillin/Clavulanic Acid Combination on Postoperative Endodontic Pain
NA trial testing Amoxicillin/Clavulanate Potassium 875 mg-125 mg oral tablet in Symptomatic Periapical Periodontitis in 72 participants. Completed in 15 March 2020.
15 March 2020
Quick facts
| Lead sponsor | Cairo University |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | quadruple |
| Primary purpose | treatment |
| Enrollment | 72 |
| Start date | 18 October 2019 |
| Primary completion | 15 March 2020 |
| Estimated completion | 15 March 2020 |
| Sites | 1 location across Egypt |
Drugs / interventions tested
- Amoxicillin/Clavulanate Potassium 875 mg-125 mg oral tablet — full drug profile →
- Oral placebo
Conditions studied
- Symptomatic Periapical Periodontitis — all drugs for Symptomatic Periapical Periodontitis →
Sponsor
Cairo University
Who can join
Adults 18 to 60, any sex, with Symptomatic Periapical Periodontitis. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The aim of this prospective, randomized, placebo controlled study is to evaluate the effect of a single preoperative dose of amoxicillin/clavulanic acid combination on post-operative pain and swelling in adult patient with symptomatic apical periodontitis.
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
-
Antibiotics for the urgent management of symptomatic irreversible pulpitis, symptomatic apical periodontitis, and localized acute apical abscess: Systematic review and meta-analysis-a report of the American Dental Association.
Tampi MP, Pilcher L, Urquhart O, Kennedy E, et al · · 2019 · cited 18× · PMID 31761029 · DOI 10.1016/j.adaj.2019.09.011 -
Systemic antibiotics for symptomatic apical periodontitis and acute apical abscess in adults.
Cope AL, Francis N, Wood F, Thompson W, et al · · 2024 · cited 9× · PMID 38712714 · DOI 10.1002/14651858.cd010136.pub4
Verify or expand the search:
- PubMed search for NCT03033147
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03033147 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Cairo University
- Last refreshed: 18 June 2021
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03033147.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing