Who is sponsoring NCT03029494?

NCT03029494 is sponsored by Croatian Science Foundation.

What drugs are being tested in NCT03029494?

Interventions in NCT03029494: stabilization splint, Placebo Oral Tablet, placebo splint, Vitamin C.

What condition does NCT03029494 study?

NCT03029494 studies Temporomandibular Disorders.

Is NCT03029494 still recruiting?

NCT03029494 is currently status unknown. Last updated 24 January 2017.

Last reviewed 2017-01-24 · How we verify

NCT03029494: ROStrO-TMD

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Oxidative Stress and Opiorphin in Temporomandibular Disorders

Status unknown NA Last updated 24 January 2017

What this trial tests

NA trial testing stabilization splint in Temporomandibular Disorders in 80 participants. Status unknown.

Timeline

1 October 2015

Primary endpoint
30 September 2018

30 September 2019

Quick facts

Lead sponsor	Croatian Science Foundation
Phase	NA
Status	Status unknown
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	diagnostic
Enrollment	80
Start date	1 October 2015
Primary completion	30 September 2018
Estimated completion	30 September 2019
Sites	1 location across Croatia

Drugs / interventions tested

stabilization splint
Placebo Oral Tablet — full drug profile →
placebo splint
Vitamin C — full drug profile →

Conditions studied

Temporomandibular Disorders — all drugs for Temporomandibular Disorders →

Sponsor

Croatian Science Foundation

Who can join

Adults 18 to 75, any sex, with Temporomandibular Disorders. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The objective of this study is to quantify salivary oxidative stress biomarkers in patients with temporomandibular disorders and to quantify recently isolated endogenous peptide opiorphin in saliva of these patients. As chronic exposure to stress may cause hyperalgesia as a result of the stress response in the hypothalamic-pituitary-adrenal axis, aim is to test this as an underlying mechanism by correlating opiorphin and oxidative stress markers to salivary cortisol levels. The aim is to assess the association of oxidative stress salivary biomarkers with muscle and joint pain and to measure opiorphin, a potential biomarker of different pathological states.

Publications & conference data

4 peer-reviewed publications reference this trial (live from Europe PMC):

Effect of occlusal splint on oxidative stress markers and psychological aspects of chronic temporomandibular pain: a randomized controlled trial.
Alajbeg IZ, Vrbanović E, Lapić I, Alajbeg I, et al · · 2020 · cited 24× · PMID 32620810 · DOI 10.1038/s41598-020-67383-x
Occlusal interventions for managing temporomandibular disorders.
Singh BP, Singh N, Jayaraman S, Kirubakaran R, et al · · 2024 · cited 22× · PMID 39282765 · DOI 10.1002/14651858.cd012850.pub2
Within-Subject Reliability and between-Subject Variability of Oxidative Stress Markers in Saliva of Healthy Subjects: A Longitudinal Pilot Study.
Alajbeg IZ, Lapić I, Rogić D, Vuletić L, et al · · 2017 · cited 20× · PMID 29269980 · DOI 10.1155/2017/2697464
Changes in salivary oxidative status, salivary cortisol, and clinical symptoms in female patients with temporomandibular disorders during occlusal splint therapy: a 3-month follow up.
Vrbanović E, Lapić I, Rogić D, Alajbeg IZ. · · 2019 · cited 14× · PMID 31170954 · DOI 10.1186/s12903-019-0791-8

Verify or expand the search:

Other trials of stabilization splint

Trials testing the same drug.

NCT06781320 — Digital Occlusal Analysis and Enamel Wear Assessment in Temporomandibular Disorder Patients Treated with Fully Digital V · NA · not yet recruiting
NCT05548894 — Comparison Between Splint and Laser in Patients Without Disc Displacement With Reduction · NA · completed
NCT04694274 — Genetic Polymorphisms and Their Association With Temporomandibular Disorders · unknown
NCT04524806 — Influence of Stabilization Splint Thickness on The Temporomandibular Disorders · NA · completed

Other recruiting trials for Temporomandibular Disorders

Currently open trials in the same condition.

NCT07452510 — Comparison of Dry Needling and Two Botulinum Toxins for Bruxism · NA · active not recruiting
NCT06553950 — Mandibular Splint vs Botox Injection in Lateral Pterygoid on Cervical Muscle Activity in Patients With Temporomandibular · NA · recruiting
NCT05720065 — Peripheral TMD Pain Mechanisms and the Effect by Botulinum Toxin A · Phase 2 · recruiting

Other Croatian Science Foundation trials

Trials by the same sponsor.

NCT04694274 — Genetic Polymorphisms and Their Association With Temporomandibular Disorders · unknown

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03029494 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Croatian Science Foundation
Last refreshed: 24 January 2017

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03029494.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing