NCT03021252 (RETORNUS-2) is a NA clinical trial of High intensity IEMT in Swallowing Disorder, sponsored by Parc de Salut Mar.

Who is sponsoring NCT03021252?

NCT03021252 is sponsored by Parc de Salut Mar.

What drugs are being tested in NCT03021252?

Interventions in NCT03021252: High intensity IEMT, Sham IEMT.

What condition does NCT03021252 study?

NCT03021252 studies Swallowing Disorder, Stroke, Respiratory Muscle Training, Malnutrition.

Is NCT03021252 still recruiting?

NCT03021252 is currently terminated. Last updated 22 September 2020.

Last reviewed 2020-09-22 · How we verify

NCT03021252: RETORNUS-2

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Respiratory Muscle Training in Stroke Swallowing Disorders

Terminated NA Last updated 22 September 2020

What this trial tests

NA trial testing High intensity IEMT in Swallowing Disorder in 50 participants. Terminated before completion.

Timeline

1 March 2017

Primary endpoint
1 February 2020

16 September 2020

Quick facts

Lead sponsor	Parc de Salut Mar
Phase	NA
Status	Terminated
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	treatment
Enrollment	50
Start date	1 March 2017
Primary completion	1 February 2020
Estimated completion	16 September 2020
Sites	2 locations across Spain

Drugs / interventions tested

High intensity IEMT
Sham IEMT

Conditions studied

Swallowing Disorder — all drugs for Swallowing Disorder →
Stroke — all drugs for Stroke →
Respiratory Muscle Training — all drugs for Respiratory Muscle Training →
Malnutrition — all drugs for Malnutrition →

Sponsor

Parc de Salut Mar — full company profile →

Who can join

Adults 18 to 80, any sex, with Swallowing Disorder or Stroke. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Clinical randomized clinical trial to assess the effectiveness of incorporating inspiratory and expiratory muscle training (IEMT) in the rehabilitation of stroke patients with dysphagia in terms of functional outcomes, comorbidities, survival and quality of life. This project also incorporates a longitudinal study to assess the clinical impact of dysphagia on body composition and nutritional status in stroke patients.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Swallowing therapy for dysphagia in acute and subacute stroke.
Bath PM, Lee HS, Everton LF. · · 2018 · cited 160× · PMID 30376602 · DOI 10.1002/14651858.cd000323.pub3
The Retornus-2 study: impact of respiratory muscle training in subacute stroke patients with dysphagia, study protocol of a double-blind randomized controlled trial.
Guillen-Sola A, Messaggi-Sartor M, Ramírez-Fuentes C, Marco E, et al · · 2021 · cited 3× · PMID 34172071 · DOI 10.1186/s13063-021-05353-y

Verify or expand the search:

Other recruiting trials for Swallowing Disorder

Currently open trials in the same condition.

NCT07205354 — Design of a Food Preference Assessment Tool for Older Patients in Geriatrics units_DYSPHAGING-PREFERENCES · recruiting
NCT07255352 — Effect of Kinesio Taping Applied to the Suprahyoid Muscles on Swallowing Safety in Patients With Post-Stroke Dysphagia · NA · recruiting
NCT07098767 — SURE Trial: Swallowing Ultrasound Reliability Evaluation Trial · recruiting
NCT06713265 — Study of the Link Between Freezing of Gait and Oropharyngeal Freezing in Parkinson's Patients · recruiting
NCT06695455 — The Effect of an Auditory Rhythmic Cue on the Frequency of Rolling in Patients with Dysphagia and Parkinson's Disease · NA · recruiting

Other Parc de Salut Mar trials

Trials by the same sponsor.

NCT06163235 — Efficacy of a Mobile Application and Semi-attendance Program in Bariatric Surgery · NA · not yet recruiting
NCT07223450 — A Study on Oral and Intranasal Forms of Oxycodone in Healthy Volunteers Using Pharmacokinetic Modeling · Phase 1 · completed
NCT07504913 — Spanish Validation of KOQUSS-40 Questionnaire: Assessing QoL of Gastric Cancer Patients After Gastrectomy: SPQUSS-41 · recruiting
NCT06806072 — BALNEOTHERAPY FOR BREAST CANCER PATIENTS UNDERGOING ENDOCRINE THERAPY · NA · not yet recruiting
NCT04084795 — Augmentation of EMDR With tDCS in the Treatment of Fibromyalgia · NA · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03021252 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Parc de Salut Mar
Last refreshed: 22 September 2020

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03021252.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing